	   SnapGene      !ÇACGCGTGTAGTCTTATGCAATACTCTTGTAGTCTTGCAACATGGTAACGATGAGTTAGCAACATGCCTTACAAGGAGAGAAAAAGCACCGTGCATGCCGATTGGTGGAAGTAAGGTGGTACGATCGTGCCTTATTAGGAAGGCAACAGACGGGTCTGACATGGATTGGACGAACCACTGAATTGCCGCATTGCAGAGATATTGTATTTAAGTGCCTAGCTCGATACAATAAACGGGTCTCTCTGGTTAGACCAGATCTGAGCCTGGGAGCTCTCTGGCTAACTAGGGAACCCACTGCTTAAGCCTCAATAAAGCTTGCCTTGAGTGCTTCAAGTAGTGTGTGCCCGTCTGTTGTGTGACTCTGGTAACTAGAGATCCCTCAGACCCTTTTAGTCAGTGTGGAAAATCTCTAGCAGTGGCGCCCGAACAGGGACCTGAAAGCGAAAGGGAAACCAGAGCTCTCTCGACGCAGGACTCGGCTTGCTGAAGCGCGCACGGCAAGAGGCGAGGGGCGGCGACTGGTGAGTACGCCAAAAATTTTGACTAGCGGAGGCTAGAAGGAGAGAGATGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAGAATTAGATCGCGATGGGAAAAAATTCGGTTAAGGCCAGGGGGAAAGAAAAAATATAAATTAAAACATATAGTATGGGCAAGCAGGGAGCTAGAACGATTCGCAGTTAATCCTGGCCTGTTAGAAACATCAGAAGGCTGTAGACAAATACTGGGACAGCTACAACCATCCCTTCAGACAGGATCAGAAGAACTTAGATCATTATATAATACAGTAGCAACCCTCTATTGTGTGCATCAAAGGATAGAGATAAAAGACACCAAGGAAGCTTTAGACAAGATAGAGGAAGAGCAAAACAAAAGTAAGACCACCGCACAGCAAGCGGCCACTGATCTTCAGACCTGGAGGAGGAGATATGAGGGACAATTGGAGAAGTGAATTATATAAATATAAAGTAGTAAAAATTGAACCATTAGGAGTAGCACCCACCAAGGCAAAGAGAAGAGTGGTGCAGAGAGAAAAAAGAGCAGTGGGAATAGGAGCTTTGTTCCTTGGGTTCTTGGGAGCAGCAGGAAGCACTATGGGCGCAGCCTCAATGACGCTGACGGTACAGGCCAGACAATTATTGTCTGGTATAGTGCAGCAGCAGAACAATTTGCTGAGGGCTATTGAGGCGCAACAGCATCTGTTGCAACTCACAGTCTGGGGCATCAAGCAGCTCCAGGCAAGAATCCTGGCTGTGGAAAGATACCTAAAGGATCAACAGCTCCTGGGGATTTGGGGTTGCTCTGGAAAACTCATTTGCACCACTGCTGTGCCTTGGAATGCTAGTTGGAGTAATAAATCTCTGGAACAGATTGGAATCACACGACCTGGATGGAGTGGGACAGAGAAATTAACAATTACACAAGCTTAATACACTCCTTAATTGAAGAATCGCAAAACCAGCAAGAAAAGAATGAACAAGAATTATTGGAATTAGATAAATGGGCAAGTTTGTGGAATTGGTTTAACATAACAAATTGGCTGTGGTATATAAAATTATTCATAATGATAGTAGGAGGCTTGGTAGGTTTAAGAATAGTTTTTGCTGTACTTTCTATAGTGAATAGAGTTAGGCAGGGATATTCACCATTATCGTTTCAGACCCACCTCCCAACCCCGAGGGGACCCGACAGGCCCGAAGGAATAGAAGAAGAAGGTGGAGAGAGAGACAGAGACAGATCCATTCGATTAGTGAACGGATCTCGACGGTATCGGTTAACTTTTAAAAGAAAAGGGGGGATTGGGGGGTACAGTGCAGGGGAAAGAATAGTAGACATAATAGCAACAGACATACAAACTAAAGAATTACAAAAACAAATTACAAAATTCAAAATTTTATCGATACTAGTATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTTTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGATCGCCTGGAGACGCCATCCACGCTGTTTTGACCTCCATAGAAGATTCTAGAGCTAGCGAATTCGCCACCatggtgagcaagggcgaggagctgttcaccggggtggtgcccatcctggtcgagctggacggcgacgtaaacggccacaagttcagcgtgtccggcgagggcgagggcgatgccacctacggcaagctgaccctgaagttcatctgcaccaccggcaagctgcccgtgccctggcccaccctcgtgaccaccctgacccacggcgtgcagtgcttcagccgctaccccgaccacatgaagcagcacgacttcttcaagtccgccatgcccgaaggctacgtccaggagcgcaccatcttcttcaaggacgacggcaactacaagacccgcgccgaggtgaagttcgagggcgacaccctggtgaaccgcatcgagctgaagggcatcgacttcaaggaggacggcaacatcctggggcacaagctggagtacaacttcaacagccacaacgtctatatcatggccgacaagcagaagaacggcatcaaggtgaacttcaagatccgccacaacatcgaggacggcagcgtgcagctcgccgaccactaccagcagaacacccccatcggcgacggccccgtgctgctgcccgacaaccactacctgagcacccagtccgccctgagcaaagaccccaacgagaagcgcgatcacatggtcctgctggagttcgtgaccgccgccgggatcactctcggcatggacgagctgtacaagGGcGGAGGtGGAAGtGGTGGAGGTGGATCCatgagctcccagattcgtcagaattattccaccgacgtggaggcagccgtcaacagcctggtcaatttgtacctgcaggcctcctacacctacctctctctgggcttctatttcgaccgcgatgatgtggctctggaaggcgtgagccacttcttccgcgaattggccgaggagaagcgcgagggctacgagcgtctcctgaagatgcaaaaccagcgtggcggccgcgctctcttccaggacatcaagaagccagctgaagatgagtggggtaaaaccccagacgccatgaaagctgccatggccctggagaaaaagctgaaccaggcccttttggatcttcatgccctgggttctgcccgcacggacccccatctctgtgacttcctggagactcacttcctagatgaggaagtgaagcttatcaagaagatgggtgaccacctgaccaacctccacaggctgggtggcccggaggctgggctgggcgagtatctcttcgaaaggctcactctcaagcacgactaactcgagGAAGGATCTGCGATCGCTCCGGTGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGGGGGAGGGGTCGGCAATTGAACGGGTGCCTAGAGAAGGTGGCGCGGGGTAAACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGGGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAACGGGTTTGCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTCCTTCACGCGCCCGCCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGTCGCGTTCTGCCGCCTCCCGCCTGTGGTGCCTCCTGAACTGCGTCCGCCGTCTAGGTAAGTTTAAAGCTCAGGTCGAGACCGGGCCTTTGTCCGGCGCTCCCTTGGAGCCTACCTAGACTCAGCCGGCTCTCCACGCTTTGCCTGACCCTGCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCTGCGCCGTTACAGATCCAAGCTGTGACCGGCGCCTACGCTAGATGACCGAGTACAAGCCCACGGTGCGCCTCGCCACCCGCGACGACGTCCCCCGGGCCGTACGCACCCTCGCCGCCGCGTTCGCCGACTACCCCGCCACGCGCCACACCGTCGACCCGGACCGCCACATCGAGCGGGTCACCGAGCTGCAAGAACTCTTCCTCACGCGCGTCGGGCTCGACATCGGCAAGGTGTGGGTCGCGGACGACGGCGCCGCGGTGGCGGTCTGGACCACGCCGGAGAGCGTCGAAGCGGGGGCGGTGTTCGCCGAGATCGGCCCGCGCATGGCCGAGTTGAGCGGTTCCCGGCTGGCCGCGCAGCAACAGATGGAAGGCCTCCTGGCGCCGCACCGGCCCAAGGAGCCCGCGTGGTTCCTGGCCACCGTCGGCGTCTCGCCCGACCACCAGGGCAAGGGTCTGGGCAGCGCCGTCGTGCTCCCCGGAGTGGAGGCGGCCGAGCGCGCCGGGGTGCCCGCCTTCCTGGAGACCTCCGCGCCCCGCAACCTCCCCTTCTACGAGCGGCTCGGCTTCACCGTCACCGCCGACGTCGAGGTGCCCGAAGGACCGCGCACCTGGTGCATGACCCGCAAGCCCGGTGCCTGAGTCGACAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTATGTTGCTCCTTTTACGCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTCCTCCTTGTATAAATCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCGTGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCACCTGTCAGCTCCTTTCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAACTCATCGCCGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTGGGCACTGACAATTCCGTGGTGTTGTCGGGGAAATCATCGTCCTTTCCTTGGCTGCTCGCCTGTGTTGCCACCTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCCTCAATCCAGCGGACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCTTCGCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCCTGGTACCTTTAAGACCAATGACTTACAAGGCAGCTGTAGATCTTAGCCACTTTTTAAAAGAAAAGGGGGGACTGGAAGGGCTAATTCACTCCCAACGAAAATAAGATCTGCTTTTTGCTTGTACTGGGTCTCTCTGGTTAGACCAGATCTGAGCCTGGGAGCTCTCTGGCTAACTAGGGAACCCACTGCTTAAGCCTCAATAAAGCTTGCCTTGAGTGCTTCAAGTAGTGTGTGCCCGTCTGTTGTGTGACTCTGGTAACTAGAGATCCCTCAGACCCTTTTAGTCAGTGTGGAAAATCTCTAGCAGTAGTAGTTCATGTCATCTTATTATTCAGTATTTATAACTTGCAAAGAAATGAATATCAGAGAGTGAGAGGAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGGCTCTAGCTATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCGGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGACTTTTGCAGAGACGGCCCAAATTCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCTAAGAAACCATTATTATCATGACATTAACCTATAAAAATAGGCGTATCACGAGGCCCTTTCGTCTCGCGCGTTTCGGTGATGACGGTGAAAACCTCTGACACATGCAGCTCCCGGAGACGGTCACAGCTTGTCTGTAAGCGGATGCCGGGAGCAGACAAGCCCGTCAGGGCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATTCAGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGCCAAGCTG  I�   .   -      *   1   /         1            5   %   +   .   .   -       -   9   +                  '   $         )   .   "      ,               "                        (          .   2   3         9      $   4   0   -   0   0   (   *      /   )   8   )   !   (   !   !      #   0   5      3   .   !   0   0   N   )         #   '            $                                "   $            &   !      "            #   )                         (       $   -   .   .   )   %   %      %   %               #   '   1                  %               #                  %          &          %      #      2   "   !   #      %                (   %      "   -      $   '         %             "   1   )         $            #   &   !   #   E   !   2   "   0   2   %      '             (            -   C   '   #   )                     *   -      (   0   ,   !          D   (          4   6      )   #   1   !   !   &        . ûQR}~Ú%§!"#0	š
ôDEFKr¨©ÿ!"ôxà	×DÆz¶È¶ o!p!- ¬½Sf«î½-K�{¨1¤0LŽ©G|ª˜
Cn‚EÇÄŸoyF… =!q! – é 8C&$	õFš¸L\s¤Þ«çÀõOØ{ ŽÉ¥ ¯ ‹!–!* ü¢`°Ûöôz	_	e	X
y
›
ÉMžÈÍ ‘ZÑ#ºÆyáîÂZsÏ·N™ · B!O!1 I 	#.T¬­°³Æõ4L[ˆ=Í1�¾	
ˆ
¦
–ÍÜ’mÁH«¨ŠÜá1oLXFpc † 
!/ i ˆ �¾g€]r.Uÿ0Okuè»2Ón‚ý}l»ƒõIÁÒ÷}Åú‹Ë¨/GW>! ¡ 
G„|ôúªâ7�Ï8¶ÈªƒZ »zÇ¡~ r! ¦ ­Öï¾Ž©¥M5	.
‹
º×UšîT™ÛDl_Î1 f q 9ÊØ‹ÿ	 	L
d
å
ÐÙß›¹]j¥Y:âý'öJauR ÙNô�³-T0!= F ¦ ° ï J! * t jx‘ Eþ%~ötv«ÓÐ˜­ç=W|’Ù'gŒ! ó rD'Ià’Gß9O•tYc¨Nµ0|±ð�Ê—! — ê ,	�#M‡¬èÁPƒƒú|§à¾i 5  öý aºõ{‚		9	Z	`	f	Æ	Y
4ÊrÃÎm�õ $x¦äM¸K[‘ªQpÍšŒXn¸O š ¬ !C!h!!% Œ ï£Üí÷w³æ=u	–	5
z
�
œ
Ý
µ QÝ»ÇEzïîo"Lö3É + Ü&Ý±ù@
NhŸ´ÄÉá‘½ÒV+0þâç ‡ yÍO‹Át©l¸ ¼ .!. xÈ™~³E	©	Ê
:5ŒÆ.¼)’[7BZpƒœç9]|�Ã!'0[p9çò¶€ÐÛ& P!¶!. ôù$p®±»®¸>¥�	]	c	J
V
‰
ÎÝ�œ€ÂûI¢ý'âH/G%JMYIL� q$ - J L Â r/13>UL´Ç“ÎÐÒÔÚ¿|“n<e¬‹1Ø?EkG­™I×d Þ !  3 A
ö\‰q2§
—ðÑ=,FÝ|2±§AãL¦ù�3_à - 
Æ@­v&5M é		0	
q
Zl¾êw¥$©§³K‹ë'hp7¼ç”ß/ŒÔ$�‡ Ð 9 j ‰ ä+Ú^sÉV¼¸ÁÄÇßƒ	é	
O
v
Ö
~Ôo•°àêƒˆ”þ>gõmQBÂ~Æ®ËêcÜÌÛÑ0�?!+ N �³¹¿h�…Ñ 1•Ñ3
Ý~Ÿ2ö2˜ÓTûR�©»X¸ÞõI ô !k! ² WÎ/òPv¿ÖàéPl¼7]ñü‡74ÀKH`­ ª §³ì¢lÚð­g
Ù
è
'(X®Ëëc¼¼„J×øŒ‘ 0 5c…Ûi	`c³í}—„%iã@  !s! Ä Ý HNl¶ï6}ƒûÐÉi«aj‘{¢ b ¢ · qéâó�£9„G¡¯°Õ ‚!' y ý t] àõ¶ñ
…«ã8	3·ø:cÚ[fn¼È1†˜ÆÈÙýF!$ “ § Ðouû'qÁ6	<	/
2
Œ
7»	MPïòBeE®m,?�ìC f ¦!³! œ äðUg¿ƒ�¯ÖÜ?N\
Î
LØ×�Üõ[\ÏR S Œ  d×¦Nó	€
epò´z§šåÊau`aQ,) ø }®‡¨“ªœÕ}	¶	¿	á	@
sŸZVž¦�Ð(•›	²UhmÞ^ãš+›[. g r �ž+ý‹ ËøŒ	Ñ×ÚàfÁòºk¦Wåþ“ßÍ7KPþó¦OË±´.‰ÞR" bÌjîÙ« 	´	M
e
æ
�uc†œ‚É�ÈCH–åÝ*1"> G ò   OQ`‹;…T	Šã(S\,µ·Æñ”Ìõ\UâP§ ± ð , Y } Ò CS:=—H+!	¢	É	Î	@^»Z;Ó÷KbvU©¹Ú#‰ž‡¥œñãâ K!v!»!   Lá+àø:F<Àõ²Eä÷—(^ + m kƒã^^?	÷uwÑ{Î®ý>X}ûÔæx !�!¬! Ê Hž’!ÿŠÁÓ³¬æú ½U™è“ÓÚñhR±  u y^&–·ê‡©
Ã,Œ._ÔJ5Ù " ]É(XA:Hº4>uë.Ã£ü
J:=¢ÊØaÔ]© :!ˆ!©! 5 ô s¿ÍsZdž¶ñš(‘²äñ� ü	JU�á48“¦Ðà{ìñ^P©�Os19ß/c8 ˜! <E	M	†	R
™HÏDøs*P–
í‡•ðþ"¨? }¯ßË [-	N‡Ã?ˆ’Îé£ÐE~³ „ûY`³  ‡DÇ*²ø$­9AŠí„H¨WÍAqj • Ÿ ¡! 	  ˜ ë Y�Ö¿
©qæ©Â%›Q¿ÉG}6ý–ï/ t  V	þ	
cŽ6j™SHU­²Ná¿( þ!O—Þÿ|ËÄp©ìû%Må)¹Ajz�BL�–«›+¯VŸ| £ ­ Ç í M!  ·÷<aï
	:	[	a	g	Z
5ƒ^…šÏK’RŽ/—�Y¹PD!i!€!  BöƒR	Ç	s§¿BhqÌ‘§N™úSqÉo 6 � !. ¡çéb»
E
�˜Ê&nžý=ˆÊö<^yËíïY?ÿ@\}‹Î2àMÖ3„Ð4 › !2!2 ¿ ›Ó¨¼(ORd™œŸäx-´ç�Ë	ì	Ó
$2!½`ÈïWhÏps‰ADOØß÷ŽZ ‰ Ò 3  # 9 � ð¤.x“½ÌîÄÍøHt	v	—	6
�
n¶RÙ¸Þc¼mFh-páì=Œ¹æ5§&4>4!{! [ º ?ÃÝl
{
Þ
¶>d{v�›Å,1Mÿ„Ê ! T ëŽûY=>Ž	ï	
�
\Qî(c~[Wð#úóÒä ü 9 áÞr«úE[Í	2	z	›	s
£
BE“Àç%µÅÊòµWÕ"bÕØè!�òŠ)zŒá	/ç$‰Ñ¹ /!e!x!Â! '¯ô²TÍëÙ	
 !ÈíP!zÔ9é ÂFY!$ '8EÝa7¨AÐ	O‹øÇÖ1Øóÿ¡?F�ž«ZPf£Ðum"p ½ 4 Ù Èç+¢ìiÌâ’‚ ¾ÚÓÕ,½Žã$ˆrÎ¥^nŸB��Ûâ
„¢ª\w¶dž] 0 _ · Ö	G
Ë
£¦�ÇÆä*6Inºÿ\knwø.C[{Íèñ?Å„Ä"(¾ ÈÑÜ;‚ - yšÄ÷F	l	
·
ö
yãç-DƒŠŸ�€³1ÿ%:èóivíÄ$@†å!&!a!’!·!½!0 @  Ô -<ÉgJº6`—LS\“«Ì?qýxàÈÌ(}�¡ÇÏj“¢+1\ÓÜ¶4·MòQ!0 U£´‘i#	ž	¤	ª	
;Hg/AM½/48„�®ùMq:Ñ^§»Üèòýq$'�j' ‘ ( «¼ú|ª¼¯z¦/	^	d	W
x
È�J£þ¹¿ß�ÅžrÎEM�Ç˜ A!n!•!* H ‡ Õ-	F\q¯²ô3T<º	
-
‡
Š
‘Ö�ü ‰S0HKÑö^‚ÍYºÆ.	! p HÉ‘K
ä
ÏÞiu†áIMæù‘/ ‹ õ%wÜ}¹ì?v²�
4q-³Ãà(oãDí &NZJ©æño™!K‹2 % !-!~!) K Á qÅó02?Kou%’pÏÑÓÙŸè#d×>@FjHK‹¥ Ï ß 8 M *V„²ÐÙÈ¡ñ”¾ÐÕßOÀÃÆ6\ÞÕ
Ø
&}û”ß“=f­ê»1A¿ÖÊQbÚÐJ�·ô!) Ã ü s4\Mkµpîßµáð
ò²ì|–$2h¢÷9bÙhFe®Ç`¯ØÔ  !! ’ ÷ |ãTf†§‚’ÕÛ>MÀ?
roŒ³­Ý]â`l[še ‹ ( Ñ BNŠ�Ë*–Šií*ªÍ	Öñ…�ºÞ¨´ðBGËä°ˆ†ÝáO›âá º!! l KG�*‚ßâ÷]9;‰•¶é¨
Ò¿-±DÒðúÓ4! 4 ¾WûTr3L	…	Q
˜@zG3	¢ìï§ðÞI'.�×`Þ‡!   †ÕÆý	b5Â>}²ìGMü@ !# ¶æ AN–þîQ	

€—¦¾%¨LÊì(i•È�*.Õ®ž{ ¢ 0 8 S š§-w’ú'NQX›žÂãÌGœ	ë	î	Ò
#[míb ouŒÄàë0rˆ@C¸ù�%ƒˆ Ñ 5 Ø 7Ç®ó`6æ§¡ê	1	y	š	r
¢
¿ëæ$Šñ÷�´�ñq�YÓ8‰è(ž€Ú	vµ\ o d!Á! ,fÕ	¶
xâª¹3Œpþi’½Ò&uìÃÇ� 3 G o Š »,vÛE[¹È	
,
w
†
ã
Çpßÿhànˆ¾Rì¨åðÌX�¹ÍŠÅ1DL!@!m!}!. òƒSjt…
$ð½ÏÔÞNÂÅ5[à>
×
ï
q±Þë’•º¡Ü80ÕgZÿadó! k Ð J�ÊÞúK	„	ü	P
Õ„?€¹y°CÊF¯ÝïÜÒÖ?šá†!0 R +6µåM¦_•Wâ¦›x	™	ê	¡
Ñ
–á#‰ìö€2o‘œn‹ÃÑÇë?­‚z � À!0 Q 5´º‚DR€Ý	#Ó4Zp"Þ 
›/mŠÉÐ§ÔäïfþW¸î¬™Càl!N O P ‘ijk†‡ˆ”Qzåæ !"2ÆÒ'deqxCV¸ù !–	3÷ãîÿ 89üýSTUV‘¶·Ö×©ª«˜ª¼()6@AB¹ºß  J !®!) ’l‰�ç×çc–ò(jryDWv—4ø3i}†u™:ÑØä7Y»Ã õ ! å À•Ò{3ÇUfA	¹úw±U’ý¾«½*¿öK ¯! lQ×ó3ñ-XwÝâ4`ºà1ÙŽ8Z®#  â 2Šè%Ø0`¬Qm½8D5˜8jr‡°»+Lt~Iax¼Ä ö !' ³ Xm�ÂÏè†¦—ž¸áê)^kszòý'ˆT˜ø$~vš«öÒ “ÂódwÀE„dù}5Á;åé - æ ´ñIB	¼
Ú
yYÌÛH/=Ì�7ƒ¬�!°! % ; � ¨–Ó|£¿m›ÛJg`’
³
û
(ìeµØ+À$ mÎ4Vc8
­
é
öxdÞ½´½}Ó(K²âì@»“þdè’¾ùÁ 6!  « Áù0íÈŸ®h
Oºû)ª¯ˆj…ùVR¿;è÷ L  ( Ÿ 6d ^†ô¢Öò.xýÈ
‹¸˜@jüa�jîô 1 ¹mØ4šç	èaî~&f-ã5á2«Ú÷�–› A  Yd…¸Ë»ÇÛ• ä[¯t!  > ] R�Üj	
´?Þë T9X € Å ë ! ›Im1”7Rgn¾9EüÜs‡ØG,M‹Å   ã 3�#OÕÛað%1B™·6™&^kˆÇÊdb¼|J½  Å ‹™!·ÓÙ#~—Ã
µ9óõy§é   Þ é&­Q„Ñ¸±j¬k’ubh£÷ !" c £ ´ ¼ Ç 8ÃéŠµr¹å$n‰U¤ð}°T›÷WC¥~“Ö $ „ JY‘Ðñ‡˜Ÿâë*‡ê_lŒÃÐþ‘ó.…H°Ó{ûþ	 \!ƒ! Ì §!9{(U™"�Õ¢:±†©³Ö n¸-€åtãóô®ù:%�ö<w¬rD"!)! z ^ÁŠ€Ê·n
}
þ
1
,¤Ú4Â6<DfOÇG!& ÖAßxîFÅ
à
†¬Û�…è;x·Ä~›Â3³æµ‡ç¢Š  Ì !! þ ”¡Åeö»Š	#
9]Õ¸ù;dú¿êÜ\o½ê)2|Éþ uÃýôáÇ'	•
ò
ä0	eÛ×¡¹9gÉCîø™Ú" ” ç ívòüJ‰7	C	s	Ä	3
�
Û
8SZÜ8ó¶n³¿xmwUD g ´! . w ¨ µ}ñ	0
z¼£ðNð%¯0º-_Žh„" ¤!±! ¿(=	
½

ÍäQCIFS˜8­í§!   ÑprÂË4Åa†ÈÆÓf>Í@ßK‚ Z_!�!# � ©ñ(�{ÀÓn�°×Ý(K´
±3ïfÝ½\€£Ð	I,m þ ) E à å÷h}À„¤œ¤ÜSbhoaI	<
Ÿ
«
º
Ï
ù
MÅ0‚”öêg{„©³6Á�  & < � —Ô@O˜¹ìå	“
ü
‰Ù*¢Ø¶ñÙ”‰¥Ô V  V{¢¯]
)=í�±]ÅST  ¯ $ë�ByŽe¨YqòLŠ˜rlyü-úÛ 7! n[W†9
Só{µ~Ô	aA¼ÇeÂ  `	§¯Oô	�
®
ê
|fu›æ)Lbbÿé“  eØÏ5±d¯qæ÷µß¾¾)Ë³ãív£”Rê7¿ídj  V ‹¯	“	i
 [°Ž)�œ°€ 6<Vú§,!”¦\�Îù !( ¬ ù ÂúXˆî?É„Ó@ú�	·	â	 
 P»*Ÿ§
³¶ƒß_lyÀ<øæ   ¯©€˜�Öo	V.?C¢«#¯	]‰†4nÖ®ôÃ%è M $  ~1ý” «~	®	º	À	Ü	A
_
+^tüWÑGe~–ik†äW›Sœéõ- 7e¡í,BJ_Ù$Œõ £ó/y�™
LóE™·ÇÌC{§æÅwíÁNmÖY<!Š!. h   ¥ Ž¬Åþ/NZjtƒ‡çÌù½4	¥
•¹ÒÛám6l§kàŽÎÚ7ôW|Š§. ) e s ò i�D×þ	+	c
ŒØ"X”`ªQsÿÒXÏb§‚{²Ø&/¦ßSfï/) ŸÇø²å<¨	É
g‹Â»l�ÿAYw›ý8LxÌPÌnµkÚõ« » g!% 2 @	º­·	Ykévï&<J{.g¦D6IâæÞK¬ø2HÖ#œÝ % ± ²ãÍë»Ùkï¬‚	è	N
f
u
ç
¯é	'‡WÊôbž6—3­éÛ_€¬H ó  Ÿ5Úbƒm�—ü? % › cnt›&pÔ|	µ	¾	žd�¥Ï'g¦dôäÉt+€P+ë B R % PR_aŒ:<üGÿebVäœÌ6T[+¶¸ÅÇò¥“•Ü¤)ñ u!   É à]†Â+‹åôI¼Íãö–]Qå°w Ø «! \Ì;È7Ï	ë÷)¹]ê-ÂOŒ�”8<¡ãÓ\¨ 9! ŒZU	†˜$@‰¬È±5VÌ•s ²  ;Ýgü<>ŒùþR|ŽŠ1ß2UÆ ì !1!L!#  " Z ¾ >˜Ë<,�	Ê	1µ¼·cV,Všg+<‹å¦þòY ã z!' &Dàª*DSZÏ	AD’ÕÙÔ¼×ìò!a×#O€>EŒªŸæˆE!c�w!1 ? ^ ~ ¶ Ó ;TI�"	k	�	£	
G@L_ãH[ËøLwß²ËÐ0ƒ¡ºÛ$ŸL
?i:ä� ¼! † ó2;Gu€t€åø˜Æ  ö p)[±ÏâJenío¿=Ýç{c²#ö\Ö_ÉÆ_¶   M…œá•V8Shì:ˆÅ©Á³ë¡FH-N 7 × ™,ùFýíýÿtÒˆÙ‡)´Œ n Ï *Lu„Mš¸xÛ7�YœÕKòy !…!% ä 4Ž“PÖÜä
bñ&Y@	øv~šl‰ÈÏþeÐÕãíü½—¾ ­! Á$_«·2CÜ#_|ßõ0¯*} , lš_õ³|Ò'áëË?~ºcç À Ž!  Ÿ¸]Ž¡·Êû,”öióSÄ ê  Œš "ÒÔÚ“"$f–˜Â
´¶%]còô # ƒ Æ Ë I7‰´ä,‹ÂÏ T­ï¯!S;VÔ9 z}’¨²ý[! ‰ Ä
ŽÔç:¾ÃÖ š¸é8CeÛ²(´íæ‰    v ¾ˆr	
¢ã`$ÅÒR¹²¾Jwglv^! D ß ö'z¡®'Ran—¸ë;
ª
Ä</“éf¢ÄH“¤  ê_…®�K6ciÚ  ÒÛ	U-B"®}Õk¦­óx“€Íø !% d ¤ ÄAI#MYsæC±ä;Š5B¦vìÀVX×¥eÙ¦ª ;!‰! ?ê¶º%oÓV;I¥¥J¬lÕ^«   È ^9:‹þ6*—ê›ä5?HÄN¤«œ7;£Ë”r × ª!& ! µ ½ :ß©Ê);YâÊØ»ñ `~±Ï/D +UføýQ;K	1>Dbh 6 … õ „ZÎdòìtëÄ¨ü[ê†³µ  Î )Kt’À™ª¶L}²ÛÚ�ô/›ÏÔâ)–
 ¿ „!%  ‚ Ñˆã+ˆ~� •ÿ�+$R\ÂŸ·7d±³ìåò|ˆ‘üÿ C  `mÑ’Äèe¥òIw’
Ì]!# 9¨":ýXã5:Ò)4á–Ééšã_¿CªUePÖ6:k¤0dª Í ƒc
K}”§|ÃÚ*Ùé#QÎá²ë•‡´2 ‚VW|â9Ñ3š›ÓÔòÂABè�‘’“RSTd2345r£Íà$
rs™!" bŽ©QVœÕíó“�£€”Žt¹Òs;%t×+ 9 š!! o¹æôS
šõWÚÖúît+žZž¤xˆÁñÿ÷<!»³à, : #!V!# G¤.��u	N	‡	Ò	ù	)
ƒ
°
ì
<3&­�•#À@osu*! Fcäö	&
Q~IÐEôù!¯;Lž÷ºÓ©t&E°% =ªR�Òhw�ÂQ— õ”¤úqu•î=�­bhu–~nÌØ›! Úp2³OÏÛ5¤.å[´.7�‰Âòø¼´; ´ H! Û Îçù�.	T
o
~
ÿ
XÛùû‰“¥ÕF=á { ‹\¤²	›öˆïÑy!…‡üE=ZP^aÈï-   _ºÂË¸õ-Ä×@Biuê,¬ŸÃ&Ÿ¥lx g"2 $!W!( zˆE×¥�³O	Ó	ù„·B‹«àî<œÃIí$†,¶tÎ‹–   Í !+!% 0HBjàvï+Gú	*
„
±
á
í
%Ü�êÜ†b–®¸¥D_´çˆ9rÃv 7/Èˆ	Æ
=éÀµÅ…Ö©ApìB £f™ " Ñy‚		‡­sä®Æ4:'y‚–§ïp¡4Ý–Á¤Xè  k ¢!- ™ ð ÿ ZgŽÆ×-h‹	JkJ`FõúÃŒ<MŠ<VevÀÍÊ4Ýä~3}'FP u  —5d¼åÀ
Rrá"ýŸÐuë7þð$ 
   ¢G÷	$
'
Ð:ØÑçÀ°(“œúÀ`Hªp¾f±ÊÿlT!' ì î •ÊÌf÷±FHªÎ^Öè	Àª	&¹RTtûø�»Ôë]*Á—0  fW	ÿ	ó
d‚”kš•û–åïú¢c!—³:ïyÃÍ éâSÈÙ
åÓ®1Â
f®>®ºOD¬õùÛ% Ä>õ³«(	–
�9¬ix_Ãt˜¿�Ir�i‘hÊâ¸Ào vþ›î7žO¢TR×ö¥«Vv»Ê+ÜØvƒ½TšÙ_ œ!  • è PK	¨[qÝ�YªÐ ó—BCÃynxµ„ ¤ ® µ N! "óÌTÀ™íÛºkµÀ©ùÊV b } " qwýß }Š89ü&NtM‚—¬´ó<Vœ,{°½< E h î I!1 Ûîÿ˜8	D	Y	t	•	Å	4
Ž
Ü
39´ÅPœ¼Üô6U‚¥æ*/·æ\{†Ž/o8Š�À¨WmÈ µ!) ø=¤	/	\	b	I
U
p
 {½�›¤Ðú;¡üŠ+¦²0Eê&G°$»“.�˜ÓŽ^#  © ¦¸·ð

†ÜP1S�ºÝj! / a x Ü b¶è‚h	„_0i…ÅâE!�!$ Ï~®ú;	à	ò	1
[

Í
6KYñLOy”Öñ±A€>Z™*`ZQ¥!²!  X | ÷„S	¡	³	È	?œtÀ‰È’ÒJOý"ˆÊ[Qð À]>	²^ùzTü ! Œ¥ÎCðr=û†	rý!™>9bÉ®7 ¨!# XC)±
¾
÷¨ipåR‘Í¢¨Ï8DGTš¾FX_pî. ” ž &  è`D
‚]„™ÉoAJp‡ÉËëú;]�îX@y˜?AL–ƒÏ3 5 œ ! ¹ Òê»�c¼Ãs
k
P'Øb=_}ZlgÎN×4Þ=Ñû !3!# qÌÌØ	ËŸÆ ÇÔ Ô¤ ]emy~AŒ¢Ïà.á#ƒ¡[ÐX!E ¢h¹Ãö
F
õ
f¢¥.–Åæ,5KRmþ>Cjmv‚‰ž÷-z­Ìðü>ÄÇ' ¦ÆÎÛçñü*#µ3hñ#…!%!`!‘!! ªÔ{©S|ëy±.
3Õ,²…¸CÞÄÐõ]n�J-Œ— !,!”!2 ‘ À û {ÄØ¦� o‘‘ØÞLž´Ô
%ñú "ég¬aá=@i¾JŠ¤EP®ÙÏ�Š Î Ó ÿ " ‰œF½))Ô)”µèÌ	a4¾ïëîÑï‡
…û&àÝŸ!¹!0 ò‘Peš�ÁåËP	Ô	í	µ
	"½åð¸aÉŒhðX'�ê%qtB-·ÂÆuø[ n ¡ c!2 F Iñ¥Zi”áï¥ÎÝù	J	w	˜	û	+
=
…
 
Ð
â
î
ÆÝ‘ë1¹ß‡½në¯E>`‰>ÄŽ |!¿!% æCy~ÅTcipwBUuo·•.h|…°t¦âí7µ¨'5?Â  á 1Ák…¥�ð,&Sƒ÷cá—q¹ªè�ºsw' $ : Ž ø/¾ÍžIHb7
‘
¬
²
»
ú
Nx©ÚÝd‡Gi.´<Qç6‚:ø5!  ' = \ ž ™Õüæ	
Ç
Š·ç>?eêÆ€Úª•Ÿíš W  ˜0APÛ†·Æ×F Šg¦è  » ð8†ä#m|Žœõò-BqC¤…Õú !!(!( Õü@ÄÞºÉíÆ&	‰	"
m
|
”
ß
ý
0Ú\+/£ÙÁw¶2B{÷N¡Ë ! ì|
ÊÃ	ð	Rï3Ä7…ÇµÞ^—ŸYT! £! �Òz£H	ä	ž
¹
ø
ˆ°)2îŒ¡zƒ¨°²ð¼5ˆÓU l ý  ® #œZA°R®{tåXpñ(‰—q¢kxÆéûì- U WŠü >ƒ—?ù	n	�	’	­	¹	
^
*]>¡FdŽ¯Ÿµ5;\‚…3 Â$¥ôçå C ñ hÆì«�Ø÷.i‚¼*	3	§	b
˜
¤
”!KlDk¶ÆËz�XvšÄ_�©rÙ6ÑMWlwÎËÕ{
mz%~.º f!' š °  ±âžs¬{	�	½	t
Xj®è&¤ó%aÎzcóf5s*èOGûêQ Ü # [ËßÇûF\Î	ÁaUö#Zˆé*óÁ‹’“°â4(Òv 8!) %CŒ	œ	CF‘0KGfÔû¶ÖÊÖ"=N‚‹=‹™*{�ž0ÞåŠäý0!y! Ö o˜(°U‡æìzbs±"Õþ Ñ^ÈÅ 	Xô"{à
Þê¹ìñ 6\³eÎÁ
S¶Éî®Õ:bB'8ÿ Ã Z! õ­½q	Ú	
:
T;A¡!­â|#Q¡½ÃvfG    9>Þ@HLB°¥×ÎGŸ¤*MI« gq   B � (©µŸŒ±çûŽ[Á¤6cv	Ë¾ * �b8a
¨P2™Ò•ÈèÁÙâ )’œ¢¾Ø@çQc¸ÑjqÌê#”	q* - F£Ñ	õ	ø	%
(
‚
¯
ë
P}€Ñ;gvÙùÁÿ 2ôKYpt”�£¬agÀö¿nº² mU! Ú ÍÙø£±	²øAhÔ«-ä%-kw€†]î1 ( /yiÐ6rãéƒ¶ÛÅ¿aª•ß´¦îo ¤CÕÜì^…•+£ë8ŸÂe˜0  í ï f–ÉË4,g°EGIjÍÏ_×ç
¿à¿‹'‰’SUsuÌüÏ3_ŽãeÀkO S!, è²šeØí8«­“N^¡ÁsÖ¾
�ªºÉ*äù ‚�¼S«ôx·Â^ ! 	X	”	§¿7�›»X˜T�Úòs–…¿¨;U§Ézla ƒ   ` ¥£­¶ß		
H
Ì
JŽ: *x±/D°é@O#Y˜)ÒÄ]Ü W W° 	>±Ço ]�¡Î7ø<ü½û W“ D ¸ Œg×	 
C
j
ô
e¡¤\ƒÈO•å+JQlIlo��ù:\|�û=WkÆÓx—ÅÍÚæðû)£
d"¡´-"•ðÝ‚Ï<Îú !( ú Ãz€êÊ“
!`ð¼Ôäÿ+è·g`ê?&éômî„­ÁÅú%Üb!“!ž!¸! Y�ATw¨†à-¯s;P�=÷¾!  ûï…ãÔ"lÅÚû%	
!
/æ[.ô EzöAžùç  !'!4 ­ "‰›ÿ@–ÉøG	m	‘	¬	¸	Â	ã	¸
÷
Qz ¯12Ã6E„‹ ž´o�„´2 ˆ¯»jwž‡ëæ6 °ÅÊªö�»)	€	¦	¼	a
—
Wi� /­Cj£$T`ÍÓu™^y‡É)5~Ðk‘Ô)z’�¯Nãé Õ ¬p	:@ya ¬°­ß]Ý¸Ä& ) A € =€ ?K´ž1˜”¤þÀá‘ÍJXos¢½×£æ·¿5õiË¹p) # .x3h™×°	7D¬M]@gÄr
Š©`‘©È”Þ,2j…óÁN R!1 V¤¢¬µŸ	Þ	
B
=IN¾9ŸPHW€—9SŽ¯ÙúNjr÷;ÒwÌ¼Ù	X(TVkÛ` ’ ! !þ•œ’!k$	«	Á	._vïþZ05…n,‡éóÿrƒ�€�êö�!! wÿ2	¥	¯	»	`
h0B£Òf¨¬W_¨¼ÝåÞ(y„œ¾( & ¡ jÝ	,-<uýXY8UVØlm¦§ËÝþ%&'wxU‚›œÚ  3   qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                        %                                                                                                                                                                                                                                                                                                                 9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           	                                             	      #                           *                                              
                                           *   
                                                                                                                       
                                            "      	   "               
         
            @   3                        
   
                  	   	      	                                    	                     &   D   (      5   .      '   .   !       §   Z      #   '   #   .       x                     %                                                                                                                                               9                                                                                                                                                                                                                                                                                                                   	                 	  #         *                
               * 
                                         
                "  	 "     
   
    @ 3        
 
      	 	  	            	       & D (  5 .  ' . !   § Z  # ' # .   x   ‰  ŠŠ  Š¦  ‹  �„  –ð  Ÿ?Œ ¯oÃ	\` ¤ªö 	C
¡Dƒy¯¿aŸ  P”9�·Ø<oÒs~û;éû¡¸` QAù	­	^
ÁtMh©Ðt b	ZÈ‡æ+ø{(È&!è%q=ŠFÃ[ä ªya <çŽY²ÃÄÞöÄR	Ž	›	Ç	Ð	¶&½-S¾4nÊø%W{„è[dNÈÌ(„�¢"(hÓÿS–DÈä !!&!D!ð2+6ã
„8œÜQ›¿û$QQûAÕù	­	^
ß
\NíTuuÐô•¼Œ	J
×'i Š¯Ä™¦	+]õí
™]÷/$«Wi«‚^s›¬™]¬¨-% ª»jèý c³´Ã¨c 8¼ýB
Ói•_ 
Ói¬¨$\4oZ'PBEìá<’~21!.Ó4 = 	]YõxöJuÓÙ"!£§K'”�Ì7¬˜D	É
‹ÅAY›æ8Úµ!lryñ—}uâ�	t
®èóè£Ñ	  'ÁPõx¦BEnì!(Ž  Ù†	
Æ ZêÓUpœñâ Uñâ ¢ø9ŸWó.ÚëS!	¢	›
÷KUî¹ñâ ›â
Æ ê Ñ‹áp€! ±	†î õx!›[ Ïª¡ëyL’_éƒ�!ße0óâ¡G �õxÊ[Í!ü ÷9b ¬¨©= 	:âU]‘Y¨õOxŠ•öJuÓƒÙ÷"€©|Ê!«¼¤
”kè«>¤IéC^Âx ÅE!ê P‹™¾zY?K£Ôû	¥	Â	H
`
—
ŽBC ¤6VWù†·Øò´üxk #,Ôy“!P›§:yŒ» |B“	6º€„¦çí®±	�/J
ÅæµÅÊ	—+É	»Œ	x YÅæ‚*ÅZE!^¨¨. ¿kd Ôû _
SÆ !	¢	›
Zê Ñ‹Ó÷KUáîp¹œñâ Â©™ ÙY?KÔû¤† Ï×¿’_kS!s[ 8Ýç¤“ëv	—	Ç	2ãMºÖ8W�íùmÈÑ$}„ž%’è=Ä¹ M!a!e!ÔûÂ	6ù´üx < [ ÙV ¾ü sßôð
â7¶÷9bÙZe»ÇÇØag	^É+Á›(Ë	ß#A‰—ûWùx|Îá•Ê¸fÿ	ó
d”kåïú!³ï
Æ êpâ«¼�	t
¤
”®èkóè£èÑ	« Pš�"qBCC‘Öåñè ’~6_¦‰öœáî<…«	?	e
æ
uŠÉ’~Uûñâ Ì_-h÷å²	í
›k¬Ü�ž_‰Œ>ÂHª_©¬™   ¢!ÁS  —OX³º„åðùÓhxð'-"Ï¡ c!G
�.Cè"ÑÙ²-ä-ø0åðð'c!’~(>éøŽ¤CI^Âx([ü]ô�¼7™·]•¶é¨
Â‹-I4Ø ýò Xxbïå
ôªâ7¶Z»Çtàñ
ãÚfÈ˜ÙzÅªêö�»)	¦	
a
—
 Ô+Cju™·^5ÐkÔômz“!ë ©©%Q–/ ÔÚ¿n‹k™d Od™œä›	ì	BEµ`ÈÕÕ!�ïW)zŒ/psA‰÷Z /!x!­©³©	:�.U¼‘Zš7ƒT9]lÂp€Ïà¾& O!	§¾�WX—SÙòr–Tk` ƒ ØÿL
d
å
›0!= F ‚	®4:Á¤­©�UšTlà¾Od™œäì	`ÈïWpsA÷Z ›	BEµÕÕ!�)zŒ/‰/!x!ûÅ%	!
/[.zö5c…—ií7	C	s	Ä	3
�
Û
8ó¶n¿´!Ænÿ\Í· þ—Od™œä›	Ö	ì	BE£ÄÇä*Iknµø[`{Èå)ÕÅÕ!z��ÄïW()zŒ� /psA‰Ü÷V;Z Ç /!x!zÅªêö�»	)	¦	
a
—
§ Ô+Cj¾�WX—Su™·Ùò^r–5ÐkÔômzTk` ƒ “!?ÃÝl
{
Þ
v1MÊ !Ûi	³ !ëyŽ¨qLly-“`êî„ú%Üž!¸!„~ r!üÆ&	”
/B÷yƒ¶ªßì…+ ¬Xj%zf5GÜ ¬î½�¨¤L˜C6SUV (vÓü(‰¯3°8� 6Y³úÐ	D g 7! y¬Xj%ƒ¶zªûfß5ì…+GñÜ ‰œ))Ì	ï‡…à¹!® #œAXpñ‰—qkxûÐoqÁe?�Å!B§hÌ§™o� B
NPH€9ŽújÒwÌÙ	Op©AB£ ­ M!d×·òv¿âóp=´|9±Ê4uÀLQÏú;	1
6LO‘Íñ¢ÏAD>X_¥!²!™ ÿ z×¥�³ù«´eà<4I—ø~ÃÎFP Í  þJXos¢¿õ¹‰ +Ú¸Ç
v
oþgmQËÌ0?!+ bk^´	�cœ­9ÈÑd>}ñW‘*æj �!¡!s¼ÁÄßÖ
°ê”c¢÷	$
'
Ð:ØÀ“œ`¾±ÿlT!=|±Ld×p´ÊuQb´	�cœ­9ÈW*j ¡!·òv¿âó94À· þ—Ö	£ÄÇä*Iknø[{å)Åz�Ä(� ÜV;Ç ® #‰œœ)A)Ì	Xpñ‰ï—qkx‡…àû¹!Øç	52Ú.‡	<@oòSUû è`D
‚]„™ÉoAJp‡ÉËëú;]�îX@y˜?AL–ƒÏ3 5 œ ¸ Œg×	 
C
j
ô
e¡¤\ƒÈO•å+JQlIlo��ù:\|�û=WkÆÓx—ÅÍÚæðû)£
d"¡´-"•ðÝ‚Ï<Îú !þ!O—Þÿ|ËÄp©ìû%Må)¹Ajz�BL�–«›+¯VŸ| £ ­ Ç í M!u y^&–·ê‡©
Ã,Œ._ÔJ5Ù Ø 7Ç®ó`6æ§¡ê	1	y	š	r
¢
¿ëæ$Šñ÷�´�ñq�YÓ8‰è(ž€Ú	vµ\ o d!Á!¡çéb»
E
�˜Ê&nžý=ˆÊö<^yËíïY?ÿ@\}‹Î2àMÖ3„Ð4 › !2!Ö o˜(°U‡æìzbs±"Õþ Ñ^ÈÅy ý t] àõ¶ñ
…«ã8	3·ø:cÚ[fn¼È1†˜ÆÈÙýF!xÈ™~³E	©	Ê
:5ŒÆ.¼)’[7BZpƒœç9]|�Ã!'0[p9çò¶€ÐÛ& P!¶!	X	”	§¿7�›»X˜T�Úòs–…¿¨;U§Ézla ƒ ' = \ ž ™Õüæ	
Ç
Š·ç>?eêÆ€Úª•Ÿíš W Ø ,7ÇÜ&x®ÈÝó`™6f~±æù§@³¡ê	1	E	y	š	©	Õ	
r
¢
¶
Ê
:¿ë5NhxŒŸÆâæ$.Š´¼ÄÉá‘ñ÷)�’ª¹½3[´Ò7BVZpƒŒœç+0pþ9�âç ]|‡�Ãñþ iqy’�YÍÓ!'08O[p‰½Òè(9‹žçò€Ú&u¶Áì	t€©ÃÇÐlvµÛ& \ o � ¸ ¼ .!P!d!¶!Á! ' = \ ž Œ˜šŸ "¸ÒÔÚ]“"$0fAPŽ™¡Õ–˜Ûüæ	
Â
Ç
Š·ç>´¶?e·Êêû,%]Æ€†·ÆÚc×”ªòôöFi•Ÿíó SŠgš¦  W Ä è ê ¿(=	
½

ÍäQCIFS˜8­í§! " Z ¾ >˜Ë<,�	Ê	1µ¼·cV,Všg+<‹å¦þòY ã z!³ Xm�ÂÏè†¦—ž¸áê)^kszòý'ˆT˜ø$~vš«öÒ.x3h™×°	7D¬M]@gÄr
Š©`‘©È”Þ,2j…óÁN R!ôù$p®±»®¸>¥�	]	c	J
V
‰
ÎÝ�œ€ÂûI¢ý'âH/G%JMYIL� q$ Î )Kt’À™ª¶L}²ÛÚ�ô/›ÏÔâ)–
 ¿ „!p Ø 7¯Ç®ó`©6æ€§H˜É�¿(‘¡Öê	1	=	o	y	š	
K
r
¢
½
ä
V¿ÏÞë
.?Cæ$Š¢«iÍñ÷#u�†¯äQ´á	CI]‰I†�4FSnÖñq�YÓ8‰è(žM€®Úæù‘ô	˜Ã%8vµ­èí M \ o d!§!Á!Û Îçù�.	T
o
~
ÿ
XÛùû‰“¥ÕF=á  /Ù     Å  ",        ",s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@Á‚ oa;ôk-š÷Ç CO-tø-j'ãCï�ùû»€ëš±óbàPÈOzëÌZE39ÄË¾cUôÈ0ó;ºôµôáF •ÑÏaS�`þUNÐþ¨­�à+�ÍÁÿÛ¸‡¯�Þ¾FRéµ`!÷áõûÝÁ€Ä›ºÅC·»Sqå92¥zS Ÿ°oy/H‚®4fôÝ ÃÎÄ¹?Œlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäañ'S÷Ï³ßÌqËÿÉÍþÏ<ÊÏÏs=ß,ÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á,uµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,[l¾¯ ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¬úÏíKïêÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8  ý  É  Ì  Ì  Ò  Ò  Ø  Ø  è  ÷  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  #K<?xml version="1.0"?><Features nextValidID="22"><Feature recentID="21" name="MCS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3577-3684" color="#ccffcc" type="standard"/></Feature><Feature recentID="20" name="FTL" directionality="1" translationMW="20020.16" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3049-3576" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="3Ã—Linker" directionality="1" translationMW="648.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3576" maxFusedRunOn="3576"><Segment range="3019-3048" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3576" maxFusedRunOn="3576"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8075" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7284-8075" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8076-8144" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4237-4836" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4843-5431" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6525-7113" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3942-4210" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5505-5738" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3718-3929" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5950-6085" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5810-5931" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8145-8249" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6123-6139" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8723-8739" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>b77c0aae-7324-4771-858d-a490ba9cd65c</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="6:24:40">2022.8.9</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ¯<StrandColors><TopStrand><ColorRange range="3576..3683" colors="black"/></TopStrand><BottomStrand><ColorRange range="3576..3683" colors="black"/></BottomStrand></StrandColors>  .S     ¬  !È        !Ès"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@Á‚ oa;ôk-š÷Ç CO-tø-j'ãCï�ùû»€ëš±óbàPÈOzëÌZE39ÄË¾cUôÈ0ó;ºôµôáF •ÑÏaS�`þUNÐþ¨­�à+�ÍÁÿÛ¸‡¯�Þ¾FRéµ`!÷áõûÝÁ€Ä›ºÅC·»Sqå0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäañ'S÷Ï³ßÌqËÿÉÍþÏ<ÊÏÏs=ß,ÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á,uµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,[l¾¯ ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¬úÏíKïêÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8  ý  É  Ì  Ì  Ò  Ò  Ø  Ø  è  ÷  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "’<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="FTL" directionality="1" translationMW="20020.16" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3049-3576" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="3Ã—Linker" directionality="1" translationMW="648.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3576" maxFusedRunOn="3576"><Segment range="3019-3048" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3576" maxFusedRunOn="3576"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7975" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7184-7975" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7976-8044" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4137-4736" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4743-5331" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6425-7013" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3842-4110" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5405-5638" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3618-3829" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5850-5985" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5710-5831" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8045-8149" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6023-6039" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8623-8639" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>b77c0aae-7324-4771-858d-a490ba9cd65c</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="6:24:26">2022.8.9</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  .R     ¬  !È        !Ès"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@Á‚  oa;ôk-š÷Ç CO-tø-j'ãCï�ùû»€ëš±óbàPÈOzëÌZE39ÄË¾cUôÈ0ó;ºôµôáF •ÑÏaS�`þUNÐþ¨­�à+�ÍÁÿÛ¸‡¯�Þ¾FRéµ`!÷áõûÝÁ€Ä›ºÅC·»Sqå0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäañ'S÷Ï³ßÌqËÿÉÍþÏ<ÊÏÏs=ß,ÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á,uµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,[l¾¯ ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¬úÏíKïêÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8  ý  É  Ì  Ì  Ò  Ò  Ø  Ø  è  ÷  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "’<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8623-8639" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6023-6039" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8045-8149" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5710-5831" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5850-5985" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3618-3829" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5405-5638" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3842-4110" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6425-7013" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="6" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4743-5331" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4137-4736" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7975" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7184-7975" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7976-8044" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3576" maxFusedRunOn="3576"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="3Ã—Linker" directionality="1" translationMW="648.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3576" maxFusedRunOn="3576"><Segment range="3019-3048" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="FTL" directionality="1" translationMW="20020.16" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3049-3576" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>b77c0aae-7324-4771-858d-a490ba9cd65c</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="2:4:14">2022.8.9</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  .=     °  !×        !×s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@Á‚’ �½„ïÑ¬´Zkß�<µÓàµ¨Ÿ�¾wçîî®jÇÌaˆ;�C!=ë¯1h<AÌ@ç.øQ�WÓ ÃÌîëÐvÔSÓ…HUÿG=…N=ƒøU8_Cú n¶?€®?7ÿnâ¾{zùAHS¦ÔQ€‡ß‡×ït8?8nëÞíMÇ”ÃÌPn1³¼#òÒDÍÛ?t¿ÄR€ °Ö…À�‘ ÌW€T†,‰àï>ªü@€_&e#I,ò+ª³\
�=táN± ìÛ»ës?<þ~óÛÜð¡,ÊãÏ¿> �¾Œ¼òä%*Tíð>¢ðÎþ�>~G´ðî÷:�‡øèí{œºŠ²«Šã<§Fõ8‡Ã>s‘‡Ä�OÜ#>Ï1Ç/ü'7û<ó+<yÿ=Ì÷|±ü=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�„±Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°m²ú¾ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.³ë?´q,¿¨>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8  ý  É  Ì  Ì  Ò  Ò  Ø  Ø  ÷    !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "y<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8638-8654" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6038-6054" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8060-8164" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5725-5846" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5865-6000" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3633-3844" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5420-5653" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3857-4125" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6440-7028" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="6" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4758-5346" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4152-4751" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7990" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7199-7990" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7991-8059" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3591" maxFusedRunOn="3591"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="3Ã—Linker" directionality="1" translationMW="963.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3591" maxFusedRunOn="3591"><Segment range="3019-3063" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="FTL" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3064-3591" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>b77c0aae-7324-4771-858d-a490ba9cd65c</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="2:3:54">2022.8.9</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  0B     ß  "”        "”s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@Á‚’ �½ƒXV"®Žç/¾8>¨ÏˆÒá£È°Ó¢øKGÙo@àîâ�H-¶Í "ëî¾:¢Ž0�Aš.˜mÊ�n®.é¶( B4öŽb*DebÑ*YuëÃMiüUu÷xëàtÐÑªR8€8åçthU¿¯bÅÄ¿Ç¾8ÚX§ˆ ZµÄPÆöP@â E 88AUˆà‚N4Óú£ª,B¨¢ê>8û!D›E ç†$0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäañ'S÷Ï³ßÌqËÿÉÍþÏ<ÊÏÏs=ß,ÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á,uµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,[l¾¯ ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¬úÏíKïêÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8  ý  É  Ì  Ì  Ò  Ò  Ø  Ø  ÷  Ã  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  $N<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="3Ã—Linker" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3780" maxFusedRunOn="3780"><Segment range="3019-3063" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="CD63" directionality="1" translationMW="25637.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3064-3780" color="#993366" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;enriched in intraluminal vesicles of late endosomes (multivesicular bodies) and in exosomes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human CD63 tetraspanin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3780" maxFusedRunOn="3780"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8179" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7388-8179" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8180-8248" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4341-4940" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4947-5535" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6629-7217" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4046-4314" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5609-5842" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3822-4033" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6054-6189" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5914-6035" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8249-8353" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6227-6243" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8827-8843" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>72db1afa-8453-4538-a3eb-fc456215fafa</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="1:59:19">2022.8.9</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  0Y   
  ß  "”        "”s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@Á‚’ ƒMƒXV"®Žç/¾8>¨ÏˆÒá£È°Ó¢øKGÙo@àîâ�H-¶Í "ëî¾:¢Ž0�Aš.˜mÊ�n®.é¶( B4öŽb*DebÑ*YuëÃMiüUu÷xëàtÐÑªR8€8åçthU¿¯bÅÄ¿Ç¾8ÚX§ˆ ZµÄPÆöP@â E 88AUˆà‚N4Óú£ª,B¨¢ê>8û!D›E ç†$0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäañ'S÷Ï³ßÌqËÿÉÍþÏ<ÊÏÏs=ß,ÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á,uµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,[l¾¯ ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¬úÏíKïêÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8  ý  É  Ì  Ì  Ò  Ò  Ø  Ø  ÷  Ã  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  $e<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="20" name="3Ã—Linker" directionality="1" translationMW="963.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3780" maxFusedRunOn="3780"><Segment range="3019-3063" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="19" name="CD63" directionality="1" translationMW="25637.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3064-3780" color="#993366" type="standard" translated="1"/><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;enriched in intraluminal vesicles of late endosomes (multivesicular bodies) and in exosomes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human CD63 tetraspanin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3780" maxFusedRunOn="3780"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8179" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7388-8179" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8180-8248" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4341-4940" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4947-5535" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6629-7217" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4046-4314" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5609-5842" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3822-4033" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6054-6189" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5914-6035" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8249-8353" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6227-6243" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8827-8843" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>72db1afa-8453-4538-a3eb-fc456215fafa</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="1:58:57">2022.8.9</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  .ô   	  Ü  "…        "…s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@Á‚’`Âˆ…+£¹ËïŽª3â4€xhò,tè¾Ñö[ÐŸø;¸£Òm³Hºû¯‚¨€ãŒãPEæ‹¦r£Û«‹ºmŠƒÍ=£ƒ˜Š‘B´J–]zðÓFZ]}Þ:Æø44j”Ž 9yÝoëØ±Eñ/ñïŽ6–)âˆ–­q1½”8ˆF€Ub8 “�4þ�hê‹ªhº�Ž>ÈQ&ÑH9Ä!‰<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9|IÔýÂ3ì÷órÿÀòs³Ï2³ÇŸóÜÏwËÁóÝ±0-ñ8Ô^ëíÌË±ÛB ,ÁÇó0¸sÁ,S 0ŠÏ°üÍƒÄ¡0¯ÃƒÌÓ]>ø3ÍðýA?2
ø=òÃ.ÏÇß@Ô€Ó<²;ü0ñ3<?>¾~ó?Í~ÿ®q0ì:ß-óÇ,B?3~Ø5?øKm~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ VÛ/«è8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ë>³ûGÁ»ú€óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N   ý  É  Ì  Ì  Ò  Ò  Ø  Ø  è  ´  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  #<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="19" name="CD63" directionality="1" translationMW="25637.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3049-3765" color="#993366" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human CD63 tetraspanin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;enriched in intraluminal vesicles of late endosomes (multivesicular bodies) and in exosomes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3765" maxFusedRunOn="3765"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8164" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7373-8164" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8165-8233" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4326-4925" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4932-5520" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6614-7202" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4031-4299" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5594-5827" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3807-4018" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6039-6174" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5899-6020" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8234-8338" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6212-6228" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8812-8828" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="3:55:7">2022.4.1</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  .õ     Ü  "…        "…s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@Á‚‘`Âˆ…+£¹ËïŽª3â4€xhò,tè¾Ñö[ÐŸø;¸£Òm³Hºû¯‚¨€ãŒãPEæ‹¦r£Û«‹ºmŠƒÍ=£ƒ˜Š‘B´J–]zðÓFZ]}Þ:Æø44j”Ž 9yÝoëØ±Eñ/ñïŽ6–)âˆ–­q1½”8ˆF€Ub8 “�4þ�hê‹ªhº�Ž>ÈQ&ÑH9Ä!‰<Åã;Â?- 4LÝ³÷KüE( h\ùBÀ%xHbÈžóê¯Ä EòfR4’Ï!rº«5À¨óÑwNëÍ»¾·3óÏçá=½Ï
Ì®<ûóâûáxËÏ.BR¥NÐ±ê/ïèçä{Oïs¨øŽŽ×¹Ë¨«*¸®3ÊtoSˆ|3ç9|IÔýÂ3ì÷órÿÀòs³Ï2³ÇŸóÜÏwËÁóÝ±0-ñ8Ô^ëíÌË±ÛB ,ÁÇó0¸sÁ,S 0ŠÏ°üÍƒÄ¡0¯ÃƒÌÓ]>ø3ÍðýA?2
ø=òÃ.ÏÇß@Ô€Ó<²;ü0ñ3<?>¾~ó?Í~ÿ®q0ì:ß-óÇ,B?3~Ø5?øKm~àiÕj!Q¡àšéyŠ;êœæ g8êXú‰¶9£¯Éƒ«j»ï¢eo‚Ž.êa¢Ê-r‚#xŠŽ×ÿx(h÷ß‹Nú¼«:¿ûù£Ü0^Û<øú?8àt°â€ÞkÈ"‹ VÛ/«è8ìøŠ=øã0¾¸ç/ëíoL¯¯Ì>8ðî0û¯2ë>³ûGÁ»ú€óïóàŸ©GÖ�CN$n“ÞªU@àP9k{õÅYFãªŽ‰à.î
GÑ¸O€Nî^@_Þ:SíeN�¡#­I"#òâˆ‡¸%äFþÑþ©-"[¹4’JØ¶é¦´š™z5EafÑè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.äæüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóì>á9¯E$„ê¨ù¨Ñ?V²[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„Hßf0ˆV|ÝÉAgÍ´3ÚÏkCŒ×Š@ÆÂ0>ë9§=81PˆãPÆ” %Ï@ªý-Ç(•qÃÒ=N   ý  É  Ì  Ì  Ò  Ò  Ø  Ø  è  ´  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  #<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="19" name="CD63" directionality="1" translationMW="25637.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3049-3765" color="#993366" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human CD63 tetraspanin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;enriched in intraluminal vesicles of late endosomes (multivesicular bodies) and in exosomes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3765" maxFusedRunOn="3765"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8164" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7373-8164" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8165-8233" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4326-4925" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4932-5520" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6614-7202" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4031-4299" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5594-5827" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3807-4018" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6039-6174" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5899-6020" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8234-8338" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6212-6228" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8812-8828" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="3:54:46">2022.4.1</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  .é     Ð  "v        "vs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@Á˜0�A…b!JèîrûãƒêŒø� <€‹ Ý:/„´}–ô çþî(ô‚ÛlÒ.¾ëàƒª 8ã øÔy¢é†Ü¨öêâî›b‚ óOhàæ"¤FP†-¥—^¼4Ñ�ŸÅW_wŽ±¾A�¥#ˆŽ^wF€E[úö,Q|Kü{ã�¥Šx€â¥«\Eoe"Q ƒ„XŽ$ãM? Z:¢Ä*€Z.£ã�²I´RqbC1A¸ÆÎð�ËH7lýÒÿJ ÃZ>DPƒ0	^R²'ƒ¼ú«ñ |™”�$³È\®ªÍp*<ô]Ó…:Ä³nï­ÌüóùøCÏosÂ„³+�>üø‚>ø^2óË�”©S´,GÀú‹Ã;úùùÓÃ»Üê>ã£µîrê*Ê®+Œò�ÔâùÎFu?pŒû=üÇ¿ð<œßìóÌ¬ñçü÷3ÝòÇð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>Ç[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢À¶Ëêú;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌºÏ¬þÑÄ°nþ <ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S  ý  É  Ì  Ì  Ò  Ò  Ø  ¥  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  #<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="19" name="CD63" directionality="1" translationMW="25637.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3034-3750" color="#993366" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human CD63 tetraspanin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;enriched in intraluminal vesicles of late endosomes (multivesicular bodies) and in exosomes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3750" maxFusedRunOn="3750"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8149" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7358-8149" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8150-8218" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4311-4910" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4917-5505" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6599-7187" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4016-4284" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5579-5812" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3792-4003" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6024-6159" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5884-6005" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8219-8323" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6197-6213" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8797-8813" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="3:54:41">2022.4.1</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  .è     Ð  "v        "vs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�@ÁØ0�A…b!JèîrûãƒêŒø� <€‹ Ý:/„´}–ô çþî(ô‚ÛlÒ.¾ëàƒª 8ã øÔy¢é†Ü¨öêâî›b‚ óOhàæ"¤FP†-¥—^¼4Ñ�ŸÅW_wŽ±¾A�¥#ˆŽ^wF€E[úö,Q|Kü{ã�¥Šx€â¥«\Eoe"Q ƒ„XŽ$ãM? Z:¢Ä*€Z.£ã�²I´RqbC1A¸ÆÎð�ËH7lýÒÿJ ÃZ>DPƒ0	^R²'ƒ¼ú«ñ |™”�$³È\®ªÍp*<ô]Ó…:Ä³nï­ÌüóùøCÏosÂ„³+�>üø‚>ø^2óË�”©S´,GÀú‹Ã;úùùÓÃ»Üê>ã£µîrê*Ê®+Œò�ÔâùÎFu?pŒû=üÇ¿ð<œßìóÌ¬ñçü÷3ÝòÇð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>Ç[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢À¶Ëêú;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌºÏ¬þÑÄ°nþ <ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S  ý  É  Ì  Ì  Ò  Ò  Ù  ¥  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  #<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="19" name="CD63" directionality="1" translationMW="25637.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3034-3750" color="#993366" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human CD63 tetraspanin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;enriched in intraluminal vesicles of late endosomes (multivesicular bodies) and in exosomes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3750" maxFusedRunOn="3750"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8149" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7358-8149" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8150-8218" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4311-4910" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4917-5505" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6599-7187" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4016-4284" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5579-5812" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3792-4003" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6024-6159" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5884-6005" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8219-8323" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6197-6213" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8797-8813" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="3:54:4">2022.4.1</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  .Í     ´  "g        "gs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�F PAaXˆRº;œ¾øàú£>#H†� "À7N‹á-e½ 9ÿƒ»Š= ¶Û4€‹¯ºø êˆ8À>5^hºa·*=º¸»¦Ø �<ÓÚ89ˆ©”!‹D©e×¯4`E§ñU×Ýã¬o�ÐcCF©Hâ ã—�Ñ Vþ½‹_ÿøãibž 8€ij×CÙAˆ�h àáV#‚	8ÓOèŽ¨±
 ‹¨øãì…mƒœB�ÃÌPn1³¼#òÒDÍÛ?t¿ÄR€ °Ö…À�‘ ÌW€T†,‰àï>ªü@€_&e#I,ò+ª³\
�=táN± ìÛ»ës?<þ~óÛÜð¡,ÊãÏ¿> �¾Œ¼òä%*Tíð>¢ðÎþ�>~G´ðî÷:�‡øèí{œºŠ²«Šã<§Fõ8‡Ã>s‘‡Ä�OÜ#>Ï1Ç/ü'7û<ó+<yÿ=Ì÷|±ü=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�„±Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°m²ú¾ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.³ë?´q,¿¨>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8  ý  –  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  #<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="19" name="CD63" directionality="1" translationMW="25637.53" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3019-3735" color="#993366" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;human CD63 tetraspanin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;enriched in intraluminal vesicles of late endosomes (multivesicular bodies) and in exosomes&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3735" maxFusedRunOn="3735"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="8134" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7343-8134" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="8135-8203" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4296-4895" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4902-5490" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6584-7172" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4001-4269" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5564-5797" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3777-3988" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6009-6144" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5869-5990" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8204-8308" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6182-6198" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8782-8798" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="3:53:58">2022.4.1</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  *ý       š        šs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬÷Ø!5N+|ý¾�Ã•ÃÝJÓ"ðÄ@Æ=ùÃS‡øR¶ã}ðÔãò?ƒ÷û!÷øpÈÒ:ÓÎÇÝ…4ÜzëRóØüPç/A3}ºëPqÃ^uÌñR±þ_6Äá@Ûµ5ÛàÔàI×­t÷\¹›`ñÔÑEÃmB­FóÝvÄ4ÈÓ³ÇÞ}4]ÿÛpÿ#Ž?}çá7ô¼þT×LÆÝ‚øàJÈ|óÀmîÃ`q8�C1A¸ÆÎð�ËH7lýÒÿJ ÃZ>DPƒ0	^R²'ƒ¼ú«ñ |™”�$³È\®ªÍp*<ô]Ó…:Ä³nï­ÌüóùøCÏosÂ„³+�>üø‚>ø^2óË�”©S´,GÀú‹Ã;úùùÓÃ»Üê>ã£µîrê*Ê®+Œò�ÔâùÎFu?pŒû=üÇ¿ð<œßìóÌ¬ñçü÷3ÝòÇð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>Ç[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢À¶Ëêú;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌºÏ¬þÑÄ°nþ <ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S  ý  É  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ç<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="regulatory_class"><V predef="other"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3162" maxFusedRunOn="3162"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7417" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6626-7417" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7418-7486" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3579-4178" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4185-4773" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5867-6455" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3284-3552" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4847-5080" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3060-3271" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5292-5427" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5152-5273" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7487-7591" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5465-5481" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8065-8081" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="3:50:11">2022.4.1</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  %     H  ×         ×s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬Z•�¼ÃÌPn1³¼#òÒDÍÛ?t¿ÄR€ °Ö…À�‘ ÌW€T†,‰àï>ªü@€_&e#I,ò+ª³\
�=táN± ìÛ»ës?<þ~óÛÜð¡,ÊãÏ¿> �¾Œ¼òä%*Tíð>¢ðÎþ�>~G´ðî÷:�‡øèí{œºŠ²«Šã<§Fõ8‡Ã>s‘‡Ä�OÜ#>Ï1Ç/ü'7û<ó+<yÿ=Ì÷|±ü=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�„±Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°m²ú¾ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.³ë?´q,¿¨>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ¦<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6710" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5919-6710" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6711-6779" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2872-3471" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3478-4066" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5160-5748" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2577-2845" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4140-4373" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2353-2564" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4585-4720" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4445-4566" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6780-6884" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4758-4774" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7358-7374" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="3:49:18">2022.4.1</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  %     H  Ö         Ös"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤‡ËFÏ�ö÷8ª½‘F¹“±jVó1A¸ÆÎð�ËH7lýÒÿJ ÃZ>DPƒ0	^R²'ƒ¼ú«ñ |™”�$³È\®ªÍp*<ô]Ó…:Ä³nï­ÌüóùøCÏosÂ„³+�>üø‚>ø^2óË�”©S´,GÀú‹Ã;úùùÓÃ»Üê>ã£µîrê*Ê®+Œò�ÔâùÎFu?pŒû=üÇ¿ð<œßìóÌ¬ñçü÷3ÝòÇð|÷lL|N5ºûs2ÀìvÃPˆ0qÃ<Â.ÜðDËÀ"³Äl?3`ñ(L+ðàó4×F¾ó|?POÌ‚¾|°Ë³ñ÷Ð5à4Ï,Žÿ�<LÏ �Ï¯�¼Ïó_¿ëœL;·Ë|ñË�ÅÌß‚6ÍOÂ>Ç[_¸uZˆThx&º^bŽú§9ˆÎ:–>¢mŽhëò`êÚ®ûè™[à£‹º˜A(ƒò‹C\ƒ ˆÞ"£‡5ÿÞ
 Ú=÷âÓ¾¯êÎ¯þþh÷¶Ï>>�Î8 ì8 7‡Zò¢À¶Ëêú;>"�~¸Ì/®9ËúÃû[ÓëëóŽ<;Œ>ëÌºÏ¬þÑÄ°nþ <ûüø'êQõ‡§PÓ‰¤÷ª•EP xZÞýqVQ¸ê£¢x»‚‘ônà»ƒ—�÷Ž”ûYS£èHëRHˆü¸¢!î	y¿´ªKH�VîM$’¶-ºi­&¦^�QXY´D„Az*hÓ¦X)Õ•5“mÕ«ueMª«xÚä¢
‹Õíµ‰ºm‹ƒ¹9¿?åï?Jóö»ÏöZª¦¦4CÄ<û¸NkÑI!:ª>Gª4GÕ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙŒ"Ÿ7F2PEYómö³ÚÐã5â€P1°ŒºÎiÏNT b8Ô1¥(	sÐ*¿KqÊ%\pô�S  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ¦<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7357-7373" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4757-4773" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6779-6883" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4444-4565" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4584-4719" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2352-2563" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4139-4372" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2576-2844" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5159-5747" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3477-4065" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2871-3470" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6709" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5918-6709" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6710-6778" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  A<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="3:2:22">2021.12.13</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  h+     H  ×         ×s"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤‡ËFÏ�ö÷8ª½‘F¹“±jVÁ¼ÃÌPn1³¼#òÒDÍÛ?t¿ÄR€ °Ö…À�‘ ÌW€T†,‰àï>ªü@€_&e#I,ò+ª³\
�=táN± ìÛ»ës?<þ~óÛÜð¡,ÊãÏ¿> �¾Œ¼òä%*Tíð>¢ðÎþ�>~G´ðî÷:�‡øèí{œºŠ²«Šã<§Fõ8‡Ã>s‘‡Ä�OÜ#>Ï1Ç/ü'7û<ó+<yÿ=Ì÷|±ü=Ûß�Eî¾ÜÌ°;°Ô"ÌpÏ0ƒ�÷<2Å0¬ñÌØ<J
ü8<Í5Ñ�Cïƒ<ßÔó ¯ƒß,2ìü}ô@¸3Ë#¿Á C3À#óëàGï3ü×ïúçÃ­òß<rÄ#ñAó7à�‡óSð�„±Ö×î�V¢	®—˜£¾©ÎbsŽ¥�¨›cš:ü˜:¶«¾ú&Vø(âî¦J ü¢Ð× È"7ˆ¨áÍ÷‚€6�}ø´ï«Àz³«ÿ¿š=Ãí³Ï�£óŽ@;(áÖ¼‚(°m²ú¾ƒŽÏˆ£ß�®3ËëŽrþ°þÖôÁúúüÃã�ãºó.³ë?´q,¿¨>ÿ>	ú”}aéÔ4âFé=ê¥QT –·¿\U”n:¨èžîà¤}„øîàåäýã¥>ÖTèú:Ô’"?.(ˆ{‚^Doíê’Ò U»“I$­‹nškI©—£TVm!^Šš4é–
ueMdÛujÝYSjªÞ6¹(‚¢õ{mbn›bàîNoÏù{ÏÒ¼ý®óýƒ‡–ª©©�ñ>ÃîšôRHAª�‘ê�Ãõk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó�¥…°õÌÀ*2hî¼ëìíáìã;+0ÄÂm;{T0–p¦÷E´—4bUMT=òUCÌ£ƒ*¯d;Ïÿ‡mÕ[íKD Å™QŸC*ÿàS¿²3»â¼�:|ø¼ú»úÀS Î®Ù;s‰	»JÂ$,¬ïS€â#qü­?8Ï¦ð—›.„½	Gqé³Þ4÷‚]“DÄ&$0ŽtJèR>^pçy& ›Œî8SÒŸ¬Q($î†ðÕÕ÷Î	0‚ª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡.Q_i¦Øv—æUd2mÄ?«.ÌÊ°†!WîØÓ¿p·N‹‰LðGSòÐ3-0"ƒ,ƒ¥æ0ÛDÑ¢xD�öc…gÍÑŒ”V|ÛC=¬ö´8Íx l#î³šsÓƒ Ž5iJ\ô
¯ÒÜr‰W=#Ô8  ?ó      ?ê®ZTR

SMP4      ;~ƒ^  xÁËÏ®Yzäß}¯Ãs|ßaï]UÝ-»«Ú–vÇN‚IÚÄ#pL@
V&(Ž‡DL2‰äLB"Ì–`À ¤p ÿ $ÄÄä£àŽº]ÕU{ß÷ŸÓZëþq]òoþ�@ú}�¦A]Œ]ôM×>>öŸ=¾7<|øâ_|ÿó}ïý¯|ùÃŸ¼ÿuü%üê_þþ�ó·Ë?÷åÀ¿ˆŸ'—<þ8yÔô#ü/ÉãÏ€?N?ÁãJ-|Â'�ö÷ÿ¯ŸâŸüø¿ñ'Ÿþw|ûOþßÿïÿ|ûú§ÿÏ/N¯_ý³_\nÛ§?¿Þ¦ëåv^Ö²å%3Åïá†ý‡�?ýïðs+ 	‚ ˜<„H@(!ER…   A
 &b@HRA)€`�I�BR@U¨TAI3Ò*hâ ®¨P€jÆâP! „˜(EEU@Ðj¥VÒ §Ú"ª9³¬›IVP!N

)&   &ˆ£BRJ
„”XAQñôT¡Û\q¤ªE ’`
 X‰ªUœÁ”­†êÌ—j…&^!éWA+,pê#u[B1H›Õh™Å\hœ¡Ú* œ*’þ D5Ëª� 7d¯â@–œé[­æÙLE|c.ý DµjLÞ‰m¥jõIï@CS›èê¶-¶µ-\¨éïƒ0+Ø¸ÖÉ¶eæ¨‘žL¿Â2Z±uzõ�	@ÛÄ4]Ýò|¯�mmjò J•âwÊ6-èÑ·»²Ü×-2:5(P×µØñøà®×OgéÃà}1M?ÈRUö±�óåžá©BaÞVû±·õtkºØŠHú ŠTfškGh¹ÏK×ho’¾ d�kwëõ´ù1<t­[n‹ 4‘âaé+P ®µºØóz?Cl‡6Ú|�tÐÕjé(`á"1öÛV§5klºÆq-KÈØ±5o%H£IßØ\Ð>íDnç‚nè€¤ÿ¤³<e6Ï€;�N¨a7k¹œ/9Æ>Ž–�º.™ÏûåôVãçCô¬dú—Àä1ç�_–²ë†¶j%Óÿ
Š”2m8ŸýùüÂà�sWÄÒï‚+Øtå~Í¡íE�*y™í³__ÿtÂÃ÷a-b”ôCb¶déw!ÌóÅÔ
 –I\7Ä2_fbÌ‹¥¿(›¹¦ï×|»û]Û;TuVi4óu.56"éo€ È¶­ÛñéP®¿»ÆñÐWs )j>·åÃ3&|ó)Ëónÿx<Mç·Oñi×‚ÞLÒ�pºãé‹|ß~ýSì~¸ok¦šþ N"c7 Ü¯l÷O¡É·ËºkcËPÉôH•¼Ut�uXßNkhÚÝ¾ßÖõf¢ƒ:S0ý]0ylëª»àzú®»¾�)Aª,ËÆÇ÷í§õõm›]$ABeÎ+Ý:]^ÐÇ÷Çåü‘qÜùXÕ(é� ¸Î¥=”ÓÇ“Ë»}?ög^nÀN‡GÝùu›ŸÛÖ™€é·@ªÔe*ññ9L§ï.ËÓq×ùv=-KhÆç÷Yn§›u{‘Í%½p™·îa�ëíò&OCM¥BÓ¿¨Ë]üû—óyŽïÜ ªQÒOAª”éÞ´ž�—o&Œ‡
€éA
%ß®Íã/c·þÙ/ðôüÔŸ$W@lyó‡_úeàþgß _|xø€n»~¼ã!öDÓ— @›
�Ç,÷�w÷´‹Z=¨¨ëŒöØ#_®‹Zõ… XÖª}­l×µ©­?Œ�¾\ßâÐ¾˜Thú„X™TÚ6,v�tªŠ¥$ËTýóøèo¯«µm¯âÍ$ý]0y,V†ý»þœ?MóöÇ}ÔùvÊûa0±ôƒ+“+m«ºÜ×ªº°åyòN[À‹¥ÿˆU¡öC¶u.¹q� ùžóÓ»¸Ío¿XÑýaˆ²žçÚ´½R¥
m+A÷e¾J}4ç¨åVºñøx±ÓzgÛ"±ô+ (Xï«÷ô0¿½~Ç!öÁ/ù<ÅZ…Hú Ë-»þù©]O_³=Ž­˜€éAˆÕ5Ãï¶å®1Æ ˆ¥Ù¸¢Ý��¸Ü¦phêñ*é¿!Æm¶°{Ûùu»µýà¬ŠXú ÛVbsá~{u®o¢K¿
X20´ÄºÍuBI@³�t}¯˜–b>2B,ý1lëf»£wùå|í»]:±D¤ÿ„X]—è†Ã½Ün'jŒc¯ëe›Ç¶‰Õ;Kÿ(BËdhÊ:½ ãA@Š¥  ÙŠ�oy}‹56ía@�>m!tƒbéKPÄê,lvÁ-÷ûM½£Ó­Ü×©clÛ°^§Íù†J±ô(b¶nÒ†¦Ì÷K°½k‹:KÄÊ-³û°ÏŸîßœ¦þÝÐ-ÎÓ¦ÏûëË/¶áÝ<IDú	1›¶Õ�B”—×�î¹Á(éKPÄl²ÆÇã¼\¾;ßö]ðæU,} ‘kf|·ÛcþˆIÛN]uÉÃ¶²Õî]Ü>]ÞN«KŸ�¶A1D¯õ^6qAbú÷Afˆïú€r[ç‚*ÅÒ¿
Äl†í�óýlù¡¡Ó rÃêû]ÞÖ{•ÐÇV�w+Áy—~ŠÐÊëÆè·ûí
4­88KDú÷ÀºIƒ«ÕÛ–ÅçM@Ë‹�w¥^kvô
§Bn¶²ßï€ùÓ¼é»Øû$}ZY”�‹°²n+,Œm“±ÜÊ­µ¦¦ßEX×ZµÛÜoç‚6T±ôG ²ä
=×ÛÙTü(ž’~V–bn#r¾B¤m½ƒªÖºnæÛ®]mšoè•>í@d™Íéq�qº\®Þw½s¦’>€`™³éÐ�íítºÜ·}h«Ó r«ív¶¬�o¨@Í¥¨‹Ns½[.]èG_ê’³ihœ8M¿
cÝÌÉà#-ÏFúè©šþ·êµ‹Qm]Vˆñš~×ºÁïŽEòå6ç}C�Ô‚[¶œ»‡‡Æ]ÎoßöË!ö¡Š@Ò²ÔêØµ>Lër› ]Q•ôj]µºÖKÆdE½xq.]@Šåœklëc3ŸNºF›JQ�¤ X7Y›0ŒîÓÅ�¥m}¨"é÷A+ys®m5¬k)ê¨‘"éwQ­°°ÕÖ±nE¨NÔWÐjÍÎ5m�º.(“ô; «3ÖCçî×+Ð÷!(¼Š¦„Õ¼²Û·qËŸJvõ&¢’~µ–E´é¼ßl±
õÂ¬VHã$ly35uÞ9I@ëÆU][ÈvÍsïàûìIQ¦Dq›T¶.ªq^	  ¨¤w �¬Û†ö1_êõºjã}ú¢M ˆ¥HŠ¹«jp‚š¥×i«œ‰
ïŒuY!áÐéíty……aØÅZk¶¨ôIÿhµn*¡mBæ�•ª©šþK˜ˆÕœ+ô¨ò<Y;¸è<ÍJ��Î¯œ«‰sôTM?†	«ÕŠ ÞkYóB6¡¾–ÅL‚FÄ*’ ‘™s�}ío÷Ó‚ÐÅ 5¡8 b$jÙ
ê¾Ût=OkÓÆ†ÞT(�t…	P¸ñíÎ±ÎyÞ‚ÄB£:¨Ò(&°øFÀ|·¬Â@_!L¿ƒ	h3shv½ïo×·Ímç|q4[7­c·ïîËtqƒg"P…¤_IT8’ÔBßÙ®Ó}�¶á×e^«Ä Þƒ
Ñô€0@dÉ°~hÝ:-×Bã¼’f™³ î€5ß¦\Ù„(š<T!éï�aöÕ\#Rë²YõpÁ|&A@Ò¯Ã …­¥ tû(uº‹Eï} °@D¦'˜Ð”ZkÍ5ºÞµ,y�‹JPX¡©BÒŸ‚0�¬äm[q¨›7	Î ”ÆR«g+Žu-FÕÎ9)y»þ€Kf©5QS ¤1�ˆ‰˜ b1I!Ä PÄDbÄDLÄˆA,=‚� b“@�!@�@ b"&BP b"&0M Nƒªw+ÅjM‘¼ bƒXê@a„À© ¸B³JuÞû …•[0˜ª@bÄ &B&Š˜ˆ	 1b Ä"Àô#P˜¼ÁE	µÎ(ÎõŒ†¥lJø .íÀÂL0ŽØÝýM¦^½öKÈé °ÖZà:“¥l®BƒSae-”Æ‰rÛ
œµ1(òTà2¢¨Jú« h›ÏÎuÑÕ:ÙF/Î‘uj× ¬ë¶ Ñ�Á¡Ü‘ƒ¤š­È¾o:geÞÊê|ì‚nr+pY	³¬â[	¥NÌÞ¼ª‚´R¶&^l«AñÞ9MkÍ¬>† ë”óœ}ÿnÈ·åf!Ê�›*ÚfE›1†ûöæÄ…8¨ÇºÌóàÔ«VIÿ6(@Ý6°º|¿\V4Ú)L¿
hTÆžÈ§’-ªÑô9(`]˜}ßûš—Z‹UÒo‚Ô|'ÇÝ0¬ç‹È±	aó"é?!fëZûþ]ÿ6M¯wqŸáOëw÷SÓïÔ 4%PV“ý°îóuvm+E”–ö @*¡�×y ë=¶ë§OñatÞ¤ÛVõ°úËõ»©‹ƒËž’~„×­ô»Ç=§—µ´}hh”´!V—ÌöØ¶óòvßù1ÒU2}Bk.íðü„|z�ú±0Ø:Ã»½ÝÛ¶Ñ„ ›rÞ½kqy¹r;týS_§ûË�» 40ý
(–µ{¤[ÏW³}Ý=nÓwsnÛø4>2__¨‡±L#1¬ejÆ§¨—óId\õ”ô×@�p…ùqï—m:Óõ®Hú( ÖƒÝ—‹6}T: äœ]ÜïÖr�Ö6¶­9¥À–9w�¨×·¬C3 Ð
MHge¹¡}~w¿|úø‚Ç~tÕƒ¦l\uì�o×ÜÑ±åíöíŠ1ÆÝxØ¶ËGp×D-JA]W‹‡îÑÏ§©9ŽÌ›Iú R¥ÞknÞûñ2}›¹Ó!<B°~Wh½?<ëýõr•½÷ã{]?½¼Õaì£«
¦¯AP8msÿîýmþøõ*íèŠ˜bÜJm½LËmrÞ!%ýu@]×2îöqù¸l‡ƒsUÁô› Ä°å­‘Ëk]E¥yúb¸Ÿ^Š}ŠI…¦B¬,E›=Ü<Ï«­P¥ª	r^|xêí~?m{Ÿ=Èô  ¶•ê‡ç‡ürÿTÆvt„VhúÏ@ œsöO�zùtºâq×„ª Óo€€ÔmÎñÐïq™º]ß{Àô N´áØM·åÆ¦m�T!²Ô©}þüù»——?¿¹Ýí›×O›íú}€©ÛÂnÿ0¬·ûrsbãÓ>wúzûvW Óo€ e+Çç±|{úzA³;˜õ|ŸECÿ´½¼f7Ä½À ¦°™Û¸we~c‹ÆïFëõuÅ»Aý0ý ×î›u½¡=ú¦h%ÓO@ª–ºäðø8Þ?½\ ‡ÁW©@.ÀplëýòZ´ZÿxhìúÝ’‡xT
Èôc€­+ÃsÛÔÓEíÑu€‚éH•zÇÖ>=€o—›78WL*4ý:€Ë¼¶Ç÷zž¾½Èqè£yT%Êf²vù~y©MÛÑeK Wý¾ÅzºiÛø&˜~�kuíaìÎ×KéüaÜßîçÉ†çÁ«)@A™«�§M—ÊÞÉãpÈËi¾>„>¸MÄÒA@2
›cÛ®ëÛ¦£ká
UjžÍï[ß¿ÝÊÖu£Â(i¨s…?¸š—»¶"«¤ßØ\ÇÈÓ�ÝÐô*¦¦`Y·:îŽ†ÛÛË0ÞQÀô;  u-.ô½lÛ}“=AH]·5Žï·×³´ÝØ@`T`ÍÖô�ÐÛíÌØî K=1nÓêö‡¸Ü>eâó¶�Q(k]äù]{Ù^®‹š—*Ê<Ínxv-OßfBûØ*.§ï°kÇ(2õ  Î[vÇ£[^¯'šÜÀò"ÍøÐÏëù\Æf€@H]Õ}°½nS74)‚Â2Uß:w»^�!¸ãÜùüîM»?> ··Û©kötY@×²‡£žî÷²B4>ìÃt:ß�nh gT©å.®ß7¶]O.@Çã³êËË©Œûf?~¨óézÛvCçŠ�©!V×q?0o/–÷!ìwƒ­ëÛæ}«æÅÒo‚)•hzØ<ßæºÃûÝ|þÅÝÚ]ßÎ¨°%#îš{™.KuÕ��Žv=�âþQ}50u`òÈuqí‡§p}½ >Œ‡Ø~7¿Ü—Á·*€Õ›ùî8t—Ëu‰¡ƒfÉÜ4<µ~¹-fƒc»Û5v?•²oZgN,ý-b¶N%,çO÷3úÖ[ò p©Ô}§õv¿ÙÞ÷K@Ëš-ìG‰—×íä†ÁC‹¤ˆ•\Âƒ?­¯Õ8Èðz\^W ;0Ì E6YÑìûi�/Ë\Ü=‘ßÞnþ¹ë<˜<¸ÙÝuO=ËõÓß?À­·éÓ�!ŒÏï«-§Ûò°k½Q³Uâ¾�¼Ÿ®•ƒk¸».íŒ¾óJúë ˆ•esnßÁæÚîƒ›n—vì¼ß\ò°mÍòøô(ÓëòÉÇÐzoç%úÖ-’¾ReññÐšMgâ8ø.«³4€"fk.M{hx?MuèšfóÎÒ Š,ÃøPÖõzžÑ÷ý®[e½^°ó-E mËAw»ëå¼¸nÜ»i~¹_ömç¡EÒ BX¶©øññ0ß_²Ô6vÕIÿ±\MÂÞËE:�jÉƒ¹®ªÏ}·-o‹]ç³s–¾!VçÊæÐß¦ë}ÚûÑ×
±ô%(beYÑî»hÓÙ«„0zØý²YèzÉÎYú±ºVç‡ÆÕmZVCìŸ(o×û¸‹€Š¥ƒ±š}Øí»s>_Öaðãa®¯p]×4f"–FP$cQ9„ÈmšMC#^ 
ÊÝÐí»üqy[¶]UŠØV7´Ïìõz}“æa÷Çe¾¿`Îýá(óí¼MZç7'–~a]ª…ñÊ6�²bûø0N—�k9†>:)’zPÄlÉÒì�—ëUa}|Ø¯åíZ]ªK_�"5—¥ÇîŠëÍ.ö¤SªÕ­dÙ= îòZãÎU¥¥ˆL£cÜø¶ÎC·P®§	86�PÅÒŠ”² ]ï]�êRÅ9WË”K¿ç—åuyuû®ñ¤
Q6+ýq·—ëííÕùîØË"÷Ó¥úç¦�˜•	Ö÷¾Y–lì} 4y”Z%ìv�–Ûyš¡&–~
Ê’wâ¶ÛtEÛ4ýq_ÜëùÕû¦q~sbé=(ÂR™›~ðX§kÞ¾ß:¬×Kö¾Û–ËåÕËcã|V±4€"Ì’K;¾Î§.4Ù‹Xú Š”µ{/y™àD}(¾Ìy±îqØ³\ÞGí}’F�%Wø}€m·	êU( Ë‹±ß?È­¼œ‚í› XêA‘º–Mûýx¯—sE;*%Àš'Ã®ÑûüÊà:B˜~±\&¸ÇvhÖë©ðà££IúMP$×Bí÷;åå®µé	EÒ¯‚¶nDÛÅæû�¯æ5� `Cñ~ØyÞ×síbJJ-9[³ë`óz±¦ÃØ=t~º_gû*%ý
È­¬.Œm,÷óE½÷Á™×ô+ ål!Ž�Ù2ß°jè»öÎí:C½uÅSÒ`Ù²ua�`ëº6Ñ+%ý%°®ÕBß+6» Jð‡qÐm>-Ðàš¢Ðt ­Ìj±	®,«V/Ñ„‚Rf•ØÄz½£cvýñ’ï÷•}×:WUÓZ^ÝÖªy½\]bQ¬¬¬Í¾ï‰ûzi«kÅQÒß ™Y�ïG¡MKXÕ·ë€i½	{é%ýE°¬ Ä¾wežnÒª¶ð&és°nR\£G>/‹WmÛ~F^¦Íµâ÷]ã×uºuÖ4ˆE•¶¡ÄØš|¿^šÎ»¦Âkú5Ô:ƒ:tÞ¶ùîéÔ‹•yÛÔ�"—éæv»ÇºÇzºÛÇèÚš3â¸¯ýz½ˆb«Žª 7šó;óÌç)¬]W·å|mZEWÊºA¤m•|¹Ð¹8Aeš.Ý½‘¶m£¬ó$îÐt
TÍr…ú~D¸–É#xõpb©RxwG—ór�9¢õ’P¤”Y$Œ£Óm›g¿sÁ;8I#h¹Ò|?:Öõëbèc€ÙlE­íc·Üg(âØÍë}àºvwçåîÜ!Æ¦À¥ïÃ,›¸ËTJuÚmÈóõR¥óæÕÒ;PÄÊZÇ±qyºß¢÷ŽReÛàÚ¡…Þò­-£FSÖ¼š�]—uYVWû0ˆqÚ&aÛ]Ô|»+‚wmQW¡\×ìÂqßûå›U�MïQT ­\Û!6Õ–y«ôÝèB©×‹µÎ5UbäZÌ�]›Ë<âÛ¡óÆÛLhÔ	Ô­ä04"y�4"KïA�Tp‹]EÎó¹ö�kœRÀR65ß6¡Ú2çE¥CgùºL.DR$�°²e°í:“|9ëÖhGqÎRBªeBÓd?/÷œ¥ñ£ïM§¼ó~ŒM)y¾èšæÐZÉWŸÕ‡ 
XË
×ˆ7]–R¤Ùu>,ó2£RëRàÆ¸ßfeïª æÕ´}ÝÖ«vÞÇ‹  ³˜kbã·r^×ÑuqÇp?/›…à¼ËÅ\Û——9›ê
AÝ„4Š•iªÅ‡þà}^îsdã�£¥Pr-nØu¾Ü§i´µP	¦€+7Õ}p°	Õ‡¶‰~µë2SÛv´¦nK^E4ªšBÒ˜<Š¬æýèeÉk.1î@lë­®®x¯RYÐ¾ÚRƒv~/Ø¦¹®Þ"Z±²qkBçc)ó‚Úh£T—z$ÏìWAì»ÈµÎ4„`’¾€Õ²ˆv>˜Õk_5ÐÑô#T[iû³Ý·ë 1x:jÎ¾ó¾–y^‰¦ëÄ,Ïk¦“V¢IúVòBm+9ÔGÕ4‚VV�óCÔÍ¦e1ÑMM?Q7«N‡+ïÛ}‹Å;…J­K)Òc>—S™eôƒyQ@R’5—BÇ ›ÏY�¶½×²ÍsÙïXËœ|®ó´)bˆ€ËVƒëý°Ø–§ŽÞzJ¥Iì;`^VF�óT­u-Ù…±·Ü×²ŠL¤ ÜôîuèX¾ÎcðÁ¦GP„µd“4ï²A$¬nV]GoËiÁÞ7¼‰JjAX¶¬2´.[¾-�5A=US’V­¬NãëvÕ¬Ñ«ƒ¤=lÅ½ÓG¯º®¯ûõX‡e¬šþ’gA6ßt­ºí¶Í%X@[EYu§Qò:oV‚6Õ	ÀtPX6±�|‹eÝ&iœ
Ab€±–²…ÐF�2¯ÅœUJò @Ìj–´…/yEÔùJ¡enâü(Z¶Û¶ŠëÛ�`½åºzxu„²s�6ZÖ¥fGÄC„L¿
¨–=¤ñð%—ÕmÞ©wb¢é„™Ð²Ë®�¡©ùVg0¢¡’¾’ 1û|¯ªùVçÒ„±–{Ù„QMÈº¡JßÍy]KPáT–b>¨®XªÂw¡[¸m¹x'>€"é·A£Šdï‘b‹e (PI4ƒ�–ÁÐ¸(y¹œy/�ô�„	k)ˆ¾�q]«8Sïœ@Ò�a‚Z²‰o ²r«
ñÞ9“ô/€fÂ6¥ô¡ñÛ¶ÔªÅ£1£m!7mˆÁ8/¶?ÆPdÞ2,"x Ôôk¨ ¡Îl‹ˆ­Ù(æé Hò L„,u.4 ËœÍqp^l]K�ÚuÔ¼,uó­k•*Æ‚ª¾iªØj›¯TÍ,ƒÚ4TTlnñN½#LD4}&Za¨ÐÆGÃ–éÄµ1Âf®éÄ)Ä ’þUÐHñ¢Ì&5htY7dTº`É"és“‡±k‚æË!Æv Ë9¯ƒ´¡-•S®Pq  ¡ÔZ©ÑyˆÍn’W1@ÒH€(RªÓ¦ú¼®Ùb3”PóbY¼w °äZàUh\”àUYXIQ�ª%!«UjoÈFN0 "¸ˆß…þMà_Š	*a …¢  P4@€0 aPŠ@
(j&ˆ� E@PA„”
!
 ‚ &j¢¦&0ÀäA5
M ! !‘<M„"'UÒ¬ÍÔ  H(Ä©ª#ˆâ¬Z…Q ÞiP˜Y–Jª¥€Éƒ"ÌHÂ‰óÁÔ™•º…âH$¯P¨AP(Ô Š%O êUVif h´Zà\ÓToXK©¬æ«7�¤g�ÈnsŒmlhëšÕMU¦'Ð¬T“Ðª7®eóUU½Jz«Ü.6­ç²dJë‹&éˆ"¹@Â±´Ø¦íÚ«xé«‡gÞ�DUÁJ+pÑy‘­’…ê½cjAa­YªAQÖµZ€Ó`�ô¯ƒVkÉ¾wZ¶µ DŠcAa-[uèüHË§zG�è”Âô#PP™53ö1Þ·M�úÖ\ú; •¹–±y¼êuBíb°ŽL;PÀb5ø¾s˜×ˆªðÎÒO@³dø¡‹sy“ 1z	 °ÎÈ~·ot½½™×T5M@êZsh‡Çe»¾m¹mZU(ÐêìJìúÂ[½4Ý«¤¿Êæo[»oŸ±|‡»ûìýŸüðšþX—)óñésä„ÿÿZ„þ@ÝN'‹í¨€Xú�RKÙ�ï—ïtc«)€�­nÏÇ¦\>Íe<8ìwîv½ÕÐ4QLÅÒ¨7Øø´çí|™|ß5jB ”bÙ5ƒ”í¾tÖvpEÒR·yêŽŸ�/ëÇ¯¯±‹kwø|œ/¿ø9Þ}~(40}	R·õá]cß}:åøÙÃ¦(ÈÙ|ÛxNÓ•è¢÷EÒ  [^£>,÷·MCô¬*–~B¬Ì‹†ç‡ÌÓ9·¡5ÅÓ#î§�«ìÆÔÄ(ÀR§qüâ©-Ÿþ|ÃçCÛT‘
Mï@@J™sût î¿8‡vh ÓP€m³ÐîZ=ÝNyèºPàŒPÙ¦›¾úì¿Åw
`8JÛ®®§+vžÚm³mo¹>¸à‹Š¥„Øf³4{¬ÓõEJÓŠi5€Ral÷[>[¢ªPËkñû=Êr~›ä¡u Š¥Ÿ€+¥ú×õvÉ¾ñæÄÒO@@J¾÷Å÷qùöçox|rY2M?Ô©4þ8ôËýlhZª€¤J)Ó†Çñ±¿½Î³�·a‘4‚ Ö2Ý†Ç'¬¯¿øø6>ïº‚BSÒY�—Ÿ>¸Ëùëe}ÄúçÏÎó§Ÿ]Ñ>ù&Ÿší|ZrÛZ<<Á}z;¹í(þ¸{À|ú¨[BÿîIíå„¼og^ª¸Z¯Y»çwy½^Ï»àl|ÿPðí7çklûãóþ6·,ºæp€¿¿ÝÙíÚ `êAˆq[évG±ût¦s5w»^_Þšq×AL?Øº {ú×ËkÅ¾’	¦÷ PPoëôî³úvþéý½è}ì‚â¶¨zh‡²æµm¼JÌ$ÛíÊïÿÒ€Ÿ}}Æþy5ˆQÒA ™ÆýÑÝïŸV»@M)Ì“øaï·ù6‹‹M�KL¥Ö[vñx˜¶Ë§i®Õ=ÿàøéÏ¿Å?}~ŽÎŒlÓ[3|õKø§_zý“w}ï†¸w·ÛuÚ�mKƒ¹MçìüÃ~?Ï—Í5�¯#T¶2c÷þCW?~»Œí ]³6ÝîÑ‹Êáøî—ÓÝ7è†½Mó§»ºÖ›Lå¼b÷Å°_^¾ÁöØ�E_N×Kì{›Ÿo·ÉvÍ`ðbéHWe^½Úçr>ÍÚ´ª¤H±ÕÚ‡–¸Ÿ9ô­ˆ€i dÛb×·˜oh{ÄÒ’%³o{®ËÝwM£â@ˆØmÊý?êÃôÓŸÃÿà¹h`úe�ºÌ«{|Œáúi«ýNšÐô¼¾næw­bé+b¶mÒ�;ž¦ŒQv"¦¿bëVÚñá1æ×mqCT[ªÅqPYÎj¡Æã{Øýõí²�]Û?L//µïv­ùjØí–Ÿ¿ÿ¥¿½üô#ð>2>uÓô¶6Îív�m÷7‡ƒ„nx®ËýtŠÁ³kv½¿äÐ´;%Ä@1LûAÖå>uN:EÒW €:íÃå~ºá8ª‚é_bVˆC™Ö¥xè	˜²Þô> Ÿ¿�r?E`ê@@ê²lÍîÃN–—â‡½‡€L=H•<Í¹ûðƒ‰ßüâþƒÃC—µ˜bu©û>×eVkÛ@HA@ê²åö¡a�?Þ›ýÑEV!œ•i®íç¼}³Õ‡a¨ÐL¦w  –Ë­=|oÇùgß�×§±«F€éAˆ•µ¶}×¬ËmÛ¢µ€HúeP lK)ûwÆËõ›Ùv!Ä]ÜétÚt¯n?ìt»œàÚÐ3T2½ÊZ§ýø½§_wÜO3JêA e+±é‡á~]BÓ˜Š¥w @ŒsiÚ#dš&u¡¯T±ôW@ˆaÎ+Ÿ?{ÿóÛ7Ë|Ø÷Ý–E*4u  Øò"ûC{›O')M´L=ŠlëœÇCÞÞ~vþeŒ40}
×:‡þC´íõÖƒuYªÀ°Ö-ûÛíŒ¦Eøl|^—×ùŽØ´ãÑçõuù$�±öc˜ï7y?ÀeKïA�îÁïv±žï³ø.
U,ý§  e-®;»Ûù^|3Âg€b–KÜ�Í:Ï·½Ä*’>Ô©øîáÐ–ót[GßÈ¦`@ e+~·?ºõô:ã9vÔJ¦? ÂuÉ|øÞ¾ÅËTã®éWVÀ2oÞ[áy>é*uxø^?}ûçxþp0G�©!f3K|èº�ÛÛR»6ºêÅÒß‚uÉ6~¾ûæüÍŸuc³K(RË½Äæx\¦é²¡ïÐÇnYÎëÖ5;¸±Ôƒ ê­®Ý»ç#ÞN—fØµý]Ô¨R¶Å‡ý.ÊòV¹÷±4‚"µ®´¦÷bS)Q‚%Ö%—Ý®–ù>ç¦ë¥’¾Éµæîñ(÷ùãælèƒ	% ˆ•e“î›¼ÞÒGK?E¬L†öÐ–åØõ�tbé=À–ÛêžÃøòñýnèJò X¾e|âÛ§Óy¿ëÝ…X×·[;4ÁQ	H)×y÷ü®ï__NŸöÆGK„X¹žôòñíCSµHú1ns‰ÝC——ËG”cïbuÉƒuÍðCO›ï³SL,} be…š|¹_ÊÆž
H@‘ZïÐþ0ŽËüÆþÐuPŠ¥¯@‘Ìšñ¸Óm:Ù<Â?�åí|»û¦´@ÅÒ{P$cŽzðk^‡�ŠZú	(¬êÃ±sóí6çVK_�"ee�Ã.”ù´ hžÞ·ËwŸ^r	ã ÀÑÒ Š”­PÆ6pYÖ¨h,yXžW×~x‡xýô¢Í¡k*-½’mcwŽçûe»sü®a¨—»ÝÚ¡¹ÈršíÐtŽ*–þaY¦»÷áºž?¾�Ãà¥ˆXzŠXYf„cw¼L§“ÏmÏÛü²,á¡ñ¡˜
ªm‹4ã£éz¾nð�sEÄÒï�"Vî¥Æ§CÔûÛ¹´C7ºNŒå:eç(S@áBì:ã¶¬�ÒˆŠ¥¿Z®*]ë¤Ü‹Á‡>ýeÐrE3Dç¦y±ƒ:“´E¬LÌãx ç·«Yß4íã8æË9wáÐªËK,k±nxXÃ}:S».˜£Xú
aÝæ*‡Ç†·ëéÜ4í>Š‰XzBX×¥æ‡cØ_¯/hžÇè«K¿Š˜Íyñã‡®Õ—×«o†±/Õ©XzBXó´Éøì»åôöfñ±küÿ_¼ìØÚ]g~ÇsÎï°¾µªj×þ÷¿í("vb#�clB'qLZà EÂ²B	‰zˆ&RÚ0Eƒ‹H�Ü�ˆývíªµÖw˜‡ñò<¤xþ÷`/î6O!´m}UŸ-ªKþÐ÷Òåô|úðùøtÛÓs˜cƒyþ!¼×>ÄÓ`ì;!“„ ùç  mwèãÓ‡7\¿­¢ã)™ä¿úÞ]æ}}}£rN

ˆ*§qv9îm=«Y äxÛ«O§eìõ~íC�¹‹iþ)¼Eãé2°­+ýS Kþ‡ ·]<QÜ¯Í%&	¦yE¼ÅÃp9¾êlLbPÀ‹—“õþ¹b>Åè.âùP„½ÔÍìá4¢¼½†).sL�o»¥Q'°m¬ã¸X/ÛJ“9ŠR<ÿìµXfNkÙnœ›kÐü[`«Åcš'ñºÕM*¦ù¶z:NçØîŸP¦(gWhþ.Ø<¥‹±ï÷-`H( Ž’Â2‹Ö·CÃ`CMÌî%4ÛÑ”MóO@G?è>M§èÇz=p	Ë|:ÛñJ&› 
°ï¥bx|PÝî_}Ò4Î= ÛáŒó,ñØVk>hêÁ<ÿ(Ò
÷8¥j»¡Å„‘ªù�A4Ù$èeokYb
Fèµ#Åy2]Ëq’`ùöVšÄ4%”ýV€¤±›ä3ÈV;q9›s;Tžú 
Ë?áì¥„>ªGY_«¨�'ê¾nG‘4L“½n+C
‘*ùïµ›§a4ÔûÖÛ 1ÐÔó— ×ÖD—I¼—c’©hþ' zñd¡bõf¢–¨š�¬(‡Ó ¬o[í0	©‹ä${+=Åa¤Ôõ8 c41££Z1œÂJÙö.-š˜åï‚^ÙÜÆ )½4DDÍ°·CB<MÒ}eƒ bpÉ÷„x‰cÝöqðÁCìùû é,<Ršj»Ý´'µØÕ@÷ê”4Ž`?ÊaM“˜å_€Ž&E›átð^÷†d‘|A¯w´q¾œ¦Oõ›Â‹Î÷÷wÍ¿‹Ù««CH�÷­€içˆ~ì¥"„A,hþôÞwõ0Ä íØö&ƒEš’ÿHï½yŒA´]ÅB„á­7�!…ÖŽ¶hÔÝ7ÛÒ4«íííš`Ã’A/ý�† ¡ûÑ*ÕÅbWŠæ¿²×c¢µ‚*#¢
�Þš›%µRÛ´K
É3gÃ0ŒgÊÚî±¤  ó{ÐÙàˆÑ¬·Þ„&�jù¿ÀEÜ;�BoÛ]ÅÂ�zr {Õ®ãQËQ»‹0ˆ÷ZÁtŽmßÃ¤–L y�Þ,†`½­Þ%è)z;ŽJKÃÈ£x·.1ˆ’¿ ½zL1=vKÉ?ÉîU’AëQ{÷!�BËæÝ\£…H~	iè­�~ì[áy|jðízåØ‡(±	Xkó´<ž‡V>¯#“Eƒ€,p†å²ÜÊëµôñ2,q J©•ŒSJ±·c—n”ˆ(’8‹C¦4„^Û
šhúŽ]Â4Io·C"†1¥ØZéì`ôè’gPÄ}Ç:Žgàæoo¡¦h&žGPà½mð0Å½ï›Ñl>õ¸—£¸«‹°WiˆÕo^i:Hìù÷Ê[4ô¶âA,uØ½u·hKiMdU×ÒŽÐÜÌ”n{‡<Nf·úæÝÂ4xèØz—(š¨
xïUS—»×žì<a©ÅUÅ‚˜Hþì^«4›§±örW`˜&˜÷;]0yD0Šæ�^[“0/¶qÝSW™`Ï#( ØjQÚh†¾µ^eœR{é t ¨ �-¨EƒøÁÚ fP’½µ†1©¢s�-˜3HÃÞ!çqj½ì›Aƒ«x¾À¨	�î€äP‰ÆîH!5©ÎhfÒ{E—)m?ŽnbÙ÷Ýš„ ½îHÂ ¯¥’â)Dô½6D—$*$xHC<%A»–jâ0Rv¯ÚS@šZ|˜D¶Ûç]‡a”¡$$?ÃÙàfQµ`+’«å3Ø¼¨†ÃáGA�0‹T¼SÄÆnh¥›»ª@ò ¥³·I­õ;×PcŒæRV¯
³`.Bc>ƒÞ½6„à½-¨usÒ[ëG3—�‡*ÄÉˆ“ì Wë:Û`ÞöuhqãÔûÖ›!!ˆæôî­kÉÍ[wBWqé�I;ûŽÞÔE5  ¶Þƒ&u«èêªÈAš5Ñ˜´UÌ¡&e+Ímˆ3Ç¾îÒ—8�SóÖ"D(�üÐ] h­D›RÔ¶Õûèaž’yÛ%ÒŒB\@@è<¤†ažq½Æ.Ó’°ï¨ Š¥.€@r€‹v¸ºÓHÖV)´`A;»»ÄDY¤;EÄ�<€pvB‚$Òw-Q`Í¿…ÿýÏÿåïtv‚ @@˜(¨C(A8…„xN�.¤R‚ @ ¤”œ@@€!„ t8�† &HwºÃ©„t÷Nˆ˜3Ò[oì *€0ˆD\„€9@Èœ@
AŠƒ BRètt§+‚'Xè�U[kŠ‰@ ‡ƒb¢Á„Þzˆ€ÁUXµu—ƒéÞZs"PÁEÍB0xg�ÝUæŸ€­{EÄcºb7‡Y5æßÁ^]ºžâHG/Ñ4IPæï�`•*Æ¨ZÚN5Xˆ]™ÿ5¶Zèq“÷µì5Â’¨0ÿ!(ð^{ð”&c½o�˜1Ò 8z­®cŠèu÷¦*KUÊvlÂyÝë­n‰ñ<‰È~_Sg˜<aþPÀÖZŸ–%ÕýåjË8©A$
Ø*©Ë÷ãx¥…$�”üÛ Š 	€¢PÄs Ñ¸ÁÇ³„¶}
ÓÃ`÷û'�”ˆ~ i^¤–ûÆ“ÙDˆäŸ‚xñjñrZêë^çKŠ�ÉB7úiLhåµNqz—¼}¾­§a6ˆ€ùû  ^‹àá4Æí~+XÚ4?~èxûTÉyš–Ã�×›Í§1ˆä/@úÑUç‡ý~ÆC*
ÏA@¼ô]Oï¿�öúUµÇ4™‹thþï @XoLóûw§ëç#„ÓYâ €Gõáò Ÿn¯�cœ¥
˜ ÒÛµ„‡÷Oe»~Ûøn¬ÌÁpÔ=>¼{ÖÏ×2?/£`þ(Ç¦i\\öûÞ4š
<ÿ„8÷ô(q-ŸmŒê*ž?‚�^÷–¥Ûõ¸Ž†Ñc“üß@ }-Ûéé;~½}ý›—Iœæ¿ è{ÕaœXîÛ~Žƒ"ˆçÒ|Oþ‡r{-j*Ïé"ëÛ7ã�ù¯@@š§eØÖ•“WñüG  ½%<¸Ÿ¶f'_|Ä¶¾üÚñ~>ï0§ä_€gÛS»˜µíÕ¢-jÚÉü%€ûÎðp:µý×[;ÏIá`þ(çNyc?¶CˆÄó¿i^tœÎ¡–+â†áù{  [ÁÓ%Êý›Ï|œÍÁü€ÂóäÇþ-ÃC2í óè«÷åé©Ô·—c~g…„ô£3].±ì/Ç ó(˜âíè!>Døý�Sš\¤ˆûÑ9,[¹ÝSˆ©GxžA@zYËxY÷on›ÍSp˜¿A‘ãØñôüQ^>}µ¥‡ç(®NÉˆºäåXãå»Ó}ûæÓjI—Ç�ïçß|ýù%.q~<cÜ¾úôm¦óó{·ëo¾’†ùòÅcñßüÍ}|z]è`þ%qß]ÆÓ©ó¾ê4„ä&žÿÈ�Û8-*ûÛO]à¨O÷ÛËqŸÎC ¬¹×¶<| o/·cšO˜?€ |sÄç©÷ë}I)X˜À�†0�ÝËm»Hbây!ÞVÑiN}¿¿M8iêA<ÿ„8g¼œÄ�[C�”ü÷@ˆ³Ï[»†Ës»^_î÷tN†. €[“áñÁ_÷O}?éüáÜÛ·¿¹Ê²ŒË‡9Õ·_—2>œOÏ—åëOß|nKŠïÓˆO÷2�5ºSò¿ !^»‡i½ßöTUÒãe©×··î˜¦§¹¶o_�þE˜�æ¿©ÒÖÃççwÓõíÓk\†wÉ?øVËøø$ëÛ×oÚÂ0½{>Ý__ºOÓ‰ê`þHo·‚éKƒ¿~s·/§A¬“ù{ Ä±×Þ}ˆr|^1½?%ë
PØo]–w>–·—R=€
´ºõéÝôú­¬�ãdUÀ<ƒÇQ�4>kº¿¾xˆayzšëýúÿbú¸Œ±(˜ÿ¤õŠtyÆp|CKÓÙ�üàûÎôn~Ú®¯÷õ’&¥ƒù/A ý^ýôîAûÛË=ŒÓà”ü €Oc`}»·6<-C¿¿p:�zÏ_‚i­Ët6lû›Ä˜$VÉ? E¼Gúz¬‰aXžŸÇýþR|II=€*½Ý”Ëe,×kÇJþñ~¬mzºœP¾ö['	âùA�8¯>,O§äo½ã¤Ö QAÓØÚ};T(ÅóŠxåÇÅlÝŽ"a0˜xþ •–ìéŒc{�,ã@ªxžA� ]—óé²í¯M.ã€nâùû  ¥îíááiÐëË8OÑ…’?‚"ÞK�á4÷ò–‚¥ÕóÏA‘Š6N†í(=hR‘Àv4³sTß_aˆ0zþŠôv �ÃiãZ{Q5q?jOÓÅÊí~+³¦å±ív-‡Ù<­øzÝU†ÁEÅó�Aˆ×£ÊüüØ^®¯»ÄÇhÝÌóï�"­}œãàõz“*=ÿGPÄÛvhz7?mÇË~­qœÍ¶·—ãM#Îï¢ÔÏßàv9ÔÚlœe¿õB„¨ç?Rû�ã‡‡tùtG‹ã`´üñÒ«œÞ=îíö©õu–aZ×¯‹âÃC1ñüG ˆûqx:_¦ÛÛõÍ1¤ØŒž¿Ez-=„çq8Ê'Ãã`ž¿ŠÐÛ½é2ŸgÙ?1†9&ˆzþsâ¾•-,_Ð—¿9t¼,â"é¥u½\.Gù|½Oél±	óÏ@‘^Z‹ã{&¬/wÚ2>œ�öë×¸¦éq~Ý^ê^/'„Fñüa•ú`Ó[Yo˜Â0¸R<ÿaó­¦ñýãñÍÛõ-¤y².êùŠx?îçwûööÕ'”Çåüh^>ƒ�æäAÄó
„ew=�/þéók¹ÎiJ.êùw@úQo!½7Ù^¾nÍÏqñÀÐëÍ8ž‡áh¯æ9‰Á<diM†i–¾­×“„1XWÞïÁçsœx{sÎÓøøn~Æ~ýv·0�ŸÆ6ìë7+‡e° ¯­ê0±î÷¤!œ‡zíëí8ø—åñ^ÖµêœFJ¾€¨€Æq6–õFÊp™åVß¾­Öß—å!´u½ÁÓøø�–—¶E
øÑ{ˆãmß_‘FŒ" Xý¶Œ¶—·{ï“žÏ'ê~SŒº@¡€·õ4<wßï·²hŒqWÍ?mwê4F¯ë=–†é²âØï˜5&°üû ˆ÷có0=ž‡~{A‰Ó0ªôü' ÅqšÆÊç·-è<"Váˆã8¶ÞÖÒ9*¦ùß�"í`Å8ÇPŽu““šhþ!Èê½/Ó)öz]E‘†¦ÐüÐKMÓYäþ²úœB´®šÿÎCjÂÀ¶oµGS1Ëÿ	E_™–Ë¸—ÿ;¯çõñ®ùÀ{éæó"xk×ml1	&ù‚^»H˜‡¡ûÚ7‰¢ù¯ÀÞjÅ0IhíðÜ]ò/A â½xg\R¨ûõîƒÅ!˜‹Bò¿…÷VTÆ@AñÃ¡i‰1íûº¡Å0Ò¢ùÃ½°Iœ—ØêZ· M¦Tcþ¶Ö*G3í~×ª¦!Š@òÿ Ž‚ƒršFàØö�QFÕ®„ä÷Š†É"{¿³÷$EÉ¿	¯^iãi´ãø¼û%ê D%ÿH
ýèUÂeœPno{À�¢
 5l6O1µõ@íÁ¦uë/¶2A	UH \Øk¥Æe­ÜÍ(Éÿdo´E“÷cwÁä‘*"ùï€¤8g8-Ñöývã “ˆª@òAw’½î¦Ùj½oÛ CŠ@�ü+�.qŒMë*ulH¡À{ë’b¬±iæbATóG°û!]¦4Xï×…†H�äÿº÷Þ%…(ÀQÙ£ˆ)¢ù÷Áî­I˜4@Š³‰hè¢p4'�…÷Ö%"HP•ü¿�ÅÙŒÁ¢’{s,@ó] âÝ]D?È&qíÚkG#¤õRÌÆ¹­·R%HRÅ•¢ùOá©ðÊf)ŽRêzT!¨+Eó_‚è9@]*8„!®¥Ó„BHþt�·ÞÝ¢±5ª!ûîUK ¡’ÿ ¤¸¸ÕäAF…jH“Á[oJÕ&t'�ü#�Pá­5�)!8š¨1º8ºPóÆÿ·Zk©BASE      -è  xÁA  ƒ°YëñÀ þµ,9TÕÙšsV3Æ\éÂ‚!Yå XssEsÒÄ­p«¶¥DAÜt‘¸�@0f*s"c!0f ÎÍRÕ©†²•jBsnš"ªm#u›¹³‘UNMÕ¹�­µ™Ìfæ†EUÈ†Z	ÂÜ“Ü¤pª„,"(†r
Â‚!h9C,„ !Ó„ 7ÁhÚfµMbÎ�
•�"¥4GLP"R	9 )‰�h•V‘E"Xc.Ø$s i.ÎÆ&04B ‡ ‚‚ ‚£C„10 a,œ¨1p’lnDAC%eÓLÑáPÑ�t0�c›¨Šf!8
ˆ,g9Ñ”D&Û©ÙõBPOS      î  xÁ±•SA E1Cä?WoÂ­†„¶(éï¿?ß^¯×÷÷Ï÷û×s?ï¯¶ß÷s*ÝyZ?œnÏ¹�¤Ïç}ßåœë©ÏºcN]O\<¦]‹mŽm5ÉîÎ5îÖÜÚÎº¶f¦»¦Ml“µ•º6G6q›²k4SŒf C2+±-5gÂ …,Ìâ0%L4`­„J35ŽlM# ÀÑ iHk$am @­	°h42i&`†ŒL±¬‰1�6€Á
Ð`h ˜dˆkÆ,,f‰�­1L0Ë²3@`‚	Œa„ƒ–1	A$ �JCÓZh`!Á !À‚L‹¦�hgŽƒþ¸;/×CNF4      `  xÁAJÃ@†á·ÑiJ�Ð ˆ¶ˆîÝ¹òßÉ<„Gñ
®Ä]]Q	H�ŽØßÉø<“‡9ènÂA(…j¤Lª±ö}ÅI^,wSöO³¦�>Ç@OCæ‹ô·î¬†£šZE:Ã-õÖv­¸é�è Õn:Ç-­ÉA÷¸)â¦%NTP‹›jÜtÊËµnqLä 8¦)‰˜¢.qª n9`‘eMÇ$¢8‰oBƒÛïÛXÍsÍûæùçFÆö,8)ú0Ö©þüå¶3�DðjŸãê}5Àt�oüíÂq>ÂŽ<áhžC~UATPATPAôÈ?ó–vƒTEXT       Ïô   xÁÍn‚@ÐïQîÀäÞoPÃ�Ö€HMº"¡1qÓØEíó÷ŒñÜC;ø€ëé8"V{cÒTVX–«½÷ÉR™f®Sl`¹™ �K‡åù9<6¡–Jî„J“ß—,Ï·0Èá±	­ôy™¡Ò0ßÆTš’ÁQ5p'©PiJGóyÐ~vúzõ…×uºLÅZ·ËŸwß¯çØ| Ö§tjRSæ8_Ú¾ðŠº‰úÚm_?¸w³!sŠ{7}-æü*
4ÓCLIP       	           [     F®ZTR

BASE      0ï  xÁA  ƒ°YëñÀ þµ,¹…3u­‰“°š90æBHçÉ*Áš›+š“&n…[µ-] 
â¦‹Ä…š€1S™�1pn–ªN5”­ÜPšsÓQm©ÛÌe˜�”@¨
pjªÎl­Íd6C07,ªB6ÔJæÆ˜ä&…S%dA1D@h�SAËb‘ ™&¹‘FÓ6«mÓpT¨	(�Ð 9b‚Á�JÈIIlDÃ¨¬°Š,ÁsÁ&™EhHs9p66�¡‰Â q8 lÈ€±@"Œ�á cáD��“ds#
bˆ*áX(›fjˆ‡"ˆ¦h¤ƒ!è¶alª¢Y nD–[¹¡()6¶Õ~Æ  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>   Ê<AlignableSequences><Sequence name="143_CMV-F_TSS20210225-027-00003_G05" ID="0" isTrace="1" sortOrder="0"/><Sequence name="P9_CMV-F_TSS20210402-028-00038_H07" ID="1" sortOrder="1"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ¦<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6710" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5919-6710" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6711-6779" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2872-3471" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3478-4066" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5160-5748" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2577-2845" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4140-4373" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2353-2564" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4585-4720" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4445-4566" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6780-6884" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4758-4774" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7358-7374" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  A<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="7:36:49">2021.4.14</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  h)      H  Ø         Øs"K¦5žè’è×`—JMv>�AU7ÈØñ �IB	ÆÈúitp.� q}áhóhÑ¢jR>NÆu•À»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒü]øTÅ@WÑ;»Ð{ŽÌÜ5Äx!'=UªLäPDF1-&”ÀZFÌ`V°¥@EU™ZUÙ’`54ä\k4¥¾ŠEvÑC‰Yà9×ÛúÑÐm^‘¶™–t“_îhˆÛT•G}AN¤uQ5]T”}ótÔÃÞ­�˜@u E!i™Y•$•ZÚA$ßßPÕD‚4DUQ4€Yê+è
èÓAMæ4ûXs‡	Ðôu¦‹‚d�4Ñu¨ášÍtÛŠ5íÒàµ4ïCQoƒˆùPmtï€€(î^Ú�÷Ž#è9(Y[¸F�mÜ~€tEiu§u:YÞúZ[5_MEQauš¤e`5* Z
—eÕ â	™VšÙa’A‚B¥J¨âz¹’D¤4k}¦Ê´~ýÄüt?EP�ÑÚÆ’ìp›
^©TU €t� TY$vY5ÑÙÕåE§UuiÕkUªlg’i�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ©™M²¤…òÑ³àG=½Î*‡ïdQ®DäÅ¬Z•°o0óŒlïü´€Ñ3vÏÝ/ñ  @,5¡p#äE3 •à!‹"x;Ïª¿ É™HÒK<…Êê¬×£ÏEÝ8S¬@;6îúÜÏÏ?Ÿ„<ö÷<(K2¸óïÏˆ#ï…ã/<¹	J•;BÄ|¨¼3¿ OŸ‘í<;½Î£áþ:;^ç.¢¬ªâ¸Ï)Ñ½N!ðÏœäañ'S÷Ï³ßÌqËÿÉÍþÏ<ÊÏÏs=ß,ÏvÄÀ·ÄãQ{¯·3,Çl5€³3Ì Âà}ÏL±L Â+<FÃó6„Â¿3Mt`PûàÏ7ÃõüÈ+à÷Ë»?}P.LòÈïðHÃÄÌðüúøûÌÿ5ûþ¹ÄÃ°ë|·Ï±üP|Íø#aüÔü#á,uµû�§U¨…F‡‚k¥æ(ïªs˜�œã©cê&ØæŽ¿&­ªï¾‰•¾
8»©„ˆ?(´5È2�â*8s_ýà £ß~-;êð¬êÿïæ�pÁ{lóãèüã�ÐÃŠxu¯ Š,[l¾¯ ã³â(÷àkŒÀrúãœ¿¬?µ½0~¾¿0øãÃ¸Ãî¼Ë¬úÏíKïêÏ¿Ï‚~¥Xzu8‘ºOz©TU �@å­ï×eŽª:'€»¸)Fá>;¸9yxéOµ•:>„Žµ$ˆ�ËŠ"à—‘ûGú¤´ˆnäÒI+bÛ¦šÒjeèÕ…›DHD¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸;“›óþ^óô¯?k¼ÿ`áåªªjcD<CÏ°û„æ½’Cª Cäz£DpýZÉm‚Ù8«â!Z)¼íÖ½Ývq<ÙR%O€#å„„åíÚZ2Œíãó«ÒÀWâÈôãial=s0C
Œš;¯:û;x{8ÎÂÊÃŒ10›NÞÕ%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªç ¸s´�qW·)@j‚ØF›UAºß‘¾©ZUaJ¥mnT™˜I^‚áÒŸXém!ù»Ln.jÊÛÙ(ø{ü²$eçÀ@éöàÿHãXgÌG÷;|;Ñ©´ÖWÓÓÁ@ñ3E ¾5êo>öô¹¥¢�ND”’³Ò–JŒ×(£Ú9ÐÛ ‹s²Ê‚`ëkNð¯×PÄ§a¿ö(�UL);ëï(´RRƒÍ"›{`¦7�–»§‹cÛÉF:®!à„ž×Ô¶¸E’&0ÇÄ£º?µœYó=Ù4^¥R;m UÊë Å^íAº|â„oJÆ%ýì�ýxn´Ûªz·Ó*à!5WACU�5UeÁX¡g¶{¯ªµšhSjmš.ØLÙ¨Xš‘U•Õ�
ó7jÿH÷áË”WÚi¶¥ù•Y›qêË³2¬!‡Uû‡v4ïÁ-Ó¢âS<ÑÔü´ËL À‹ àéyŒ6Ñ4hž#}˜Â!Yótc%UŸ6ÐÏk=­3^(Àû¬æœôàÅ@#�CR€—=«ô·¢UÇHõ8  ?ó      ?ê®ZTR

SMP4      ;~ƒ^  xÁËÏ®Yzäß}¯Ãs|ßaï]UÝ-»«Ú–vÇN‚IÚÄ#pL@
V&(Ž‡DL2‰äLB"Ì–`À ¤p ÿ $ÄÄä£àŽº]ÕU{ß÷ŸÓZëþq]òoþ�@ú}�¦A]Œ]ôM×>>öŸ=¾7<|øâ_|ÿó}ïý¯|ùÃŸ¼ÿuü%üê_þþ�ó·Ë?÷åÀ¿ˆŸ'—<þ8yÔô#ü/ÉãÏ€?N?ÁãJ-|Â'�ö÷ÿ¯ŸâŸüø¿ñ'Ÿþw|ûOþßÿïÿ|ûú§ÿÏ/N¯_ý³_\nÛ§?¿Þ¦ëåv^Ö²å%3Åïá†ý‡�?ýïðs+ 	‚ ˜<„H@(!ER…   A
 &b@HRA)€`�I�BR@U¨TAI3Ò*hâ ®¨P€jÆâP! „˜(EEU@Ðj¥VÒ §Ú"ª9³¬›IVP!N

)&   &ˆ£BRJ
„”XAQñôT¡Û\q¤ªE ’`
 X‰ªUœÁ”­†êÌ—j…&^!éWA+,pê#u[B1H›Õh™Å\hœ¡Ú* œ*’þ D5Ëª� 7d¯â@–œé[­æÙLE|c.ý DµjLÞ‰m¥jõIï@CS›èê¶-¶µ-\¨éïƒ0+Ø¸ÖÉ¶eæ¨‘žL¿Â2Z±uzõ�	@ÛÄ4]Ýò|¯�mmjò J•âwÊ6-èÑ·»²Ü×-2:5(P×µØñøà®×OgéÃà}1M?ÈRUö±�óåžá©BaÞVû±·õtkºØŠHú ŠTfškGh¹ÏK×ho’¾ d�kwëõ´ù1<t­[n‹ 4‘âaé+P ®µºØóz?Cl‡6Ú|�tÐÕjé(`á"1öÛV§5klºÆq-KÈØ±5o%H£IßØ\Ð>íDnç‚nè€¤ÿ¤³<e6Ï€;�N¨a7k¹œ/9Æ>Ž–�º.™ÏûåôVãçCô¬dú—Àä1ç�_–²ë†¶j%Óÿ
Š”2m8ŸýùüÂà�sWÄÒï‚+Øtå~Í¡íE�*y™í³__ÿtÂÃ÷a-b”ôCb¶déw!ÌóÅÔ
 –I\7Ä2_fbÌ‹¥¿(›¹¦ï×|»û]Û;TuVi4óu.56"éo€ È¶­ÛñéP®¿»ÆñÐWs )j>·åÃ3&|ó)Ëónÿx<Mç·Oñi×‚ÞLÒ�pºãé‹|ß~ýSì~¸ok¦šþ N"c7 Ü¯l÷O¡É·ËºkcËPÉôH•¼Ut�uXßNkhÚÝ¾ßÖõf¢ƒ:S0ý]0ylëª»àzú®»¾�)Aª,ËÆÇ÷í§õõm›]$ABeÎ+Ý:]^ÐÇ÷Çåü‘qÜùXÕ(é� ¸Î¥=”ÓÇ“Ë»}?ög^nÀN‡GÝùu›ŸÛÖ™€é·@ªÔe*ññ9L§ï.ËÓq×ùv=-KhÆç÷Yn§›u{‘Í%½p™·îa�ëíò&OCM¥BÓ¿¨Ë]üû—óyŽïÜ ªQÒOAª”éÞ´ž�—o&Œ‡
€éA
%ß®Íã/c·þÙ/ðôüÔŸ$W@lyó‡_úeàþgß _|xø€n»~¼ã!öDÓ— @›
�Ç,÷�w÷´‹Z=¨¨ëŒöØ#_®‹Zõ… XÖª}­l×µ©­?Œ�¾\ßâÐ¾˜Thú„X™TÚ6,v�tªŠ¥$ËTýóøèo¯«µm¯âÍ$ý]0y,V†ý»þœ?MóöÇ}ÔùvÊûa0±ôƒ+“+m«ºÜ×ªº°åyòN[À‹¥ÿˆU¡öC¶u.¹q� ùžóÓ»¸Ío¿XÑýaˆ²žçÚ´½R¥
m+A÷e¾J}4ç¨åVºñøx±ÓzgÛ"±ô+ (Xï«÷ô0¿½~Ç!öÁ/ù<ÅZ…Hú Ë-»þù©]O_³=Ž­˜€éAˆÕ5Ãï¶å®1Æ ˆ¥Ù¸¢Ý��¸Ü¦phêñ*é¿!Æm¶°{Ûùu»µýà¬ŠXú ÛVbsá~{u®o¢K¿
X20´ÄºÍuBI@³�t}¯˜–b>2B,ý1lëf»£wùå|í»]:±D¤ÿ„X]—è†Ã½Ün'jŒc¯ëe›Ç¶‰Õ;Kÿ(BËdhÊ:½ ãA@Š¥  ÙŠ�oy}‹56ía@�>m!tƒbéKPÄê,lvÁ-÷ûM½£Ó­Ü×©clÛ°^§Íù†J±ô(b¶nÒ†¦Ì÷K°½k‹:KÄÊ-³û°ÏŸîßœ¦þÝÐ-ÎÓ¦ÏûëË/¶áÝ<IDú	1›¶Õ�B”—×�î¹Á(éKPÄl²ÆÇã¼\¾;ßö]ðæU,} ‘kf|·ÛcþˆIÛN]uÉÃ¶²Õî]Ü>]ÞN«KŸ�¶A1D¯õ^6qAbú÷Afˆïú€r[ç‚*ÅÒ¿
Äl†í�óýlù¡¡Ó rÃêû]ÞÖ{•ÐÇV�w+Áy—~ŠÐÊëÆè·ûí
4­88KDú÷ÀºIƒ«ÕÛ–ÅçM@Ë‹�w¥^kvô
§Bn¶²ßï€ùÓ¼é»Øû$}ZY”�‹°²n+,Œm“±ÜÊ­µ¦¦ßEX×ZµÛÜoç‚6T±ôG ²ä
=×ÛÙTü(ž’~V–bn#r¾B¤m½ƒªÖºnæÛ®]mšoè•>í@d™Íéq�qº\®Þw½s¦’>€`™³éÐ�íítºÜ·}h«Ó r«ív¶¬�o¨@Í¥¨‹Ns½[.]èG_ê’³ihœ8M¿
cÝÌÉà#-ÏFúè©šþ·êµ‹Qm]Vˆñš~×ºÁïŽEòå6ç}C�Ô‚[¶œ»‡‡Æ]ÎoßöË!ö¡Š@Ò²ÔêØµ>Lër› ]Q•ôj]µºÖKÆdE½xq.]@Šåœklëc3ŸNºF›JQ�¤ X7Y›0ŒîÓÅ�¥m}¨"é÷A+ys®m5¬k)ê¨‘"éwQ­°°ÕÖ±nE¨NÔWÐjÍÎ5m�º.(“ô; «3ÖCçî×+Ð÷!(¼Š¦„Õ¼²Û·qËŸJvõ&¢’~µ–E´é¼ßl±
õÂ¬VHã$ly35uÞ9I@ëÆU][ÈvÍsïàûìIQ¦Dq›T¶.ªq^	  ¨¤w �¬Û†ö1_êõºjã}ú¢M ˆ¥HŠ¹«jp‚š¥×i«œ‰
ïŒuY!áÐéíty……aØÅZk¶¨ôIÿhµn*¡mBæ�•ª©šþK˜ˆÕœ+ô¨ò<Y;¸è<ÍJ��Î¯œ«‰sôTM?†	«ÕŠ ÞkYóB6¡¾–ÅL‚FÄ*’ ‘™s�}ío÷Ó‚ÐÅ 5¡8 b$jÙ
ê¾Ût=OkÓÆ†ÞT(�t…	P¸ñíÎ±ÎyÞ‚ÄB£:¨Ò(&°øFÀ|·¬Â@_!L¿ƒ	h3shv½ïo×·Ímç|q4[7­c·ïîËtqƒg"P…¤_IT8’ÔBßÙ®Ó}�¶á×e^«Ä Þƒ
Ñô€0@dÉ°~hÝ:-×Bã¼’f™³ î€5ß¦\Ù„(š<T!éï�aöÕ\#Rë²YõpÁ|&A@Ò¯Ã …­¥ tû(uº‹Eï} °@D¦'˜Ð”ZkÍ5ºÞµ,y�‹JPX¡©BÒŸ‚0�¬äm[q¨›7	Î ”ÆR«g+Žu-FÕÎ9)y»þ€Kf©5QS ¤1�ˆ‰˜ b1I!Ä PÄDbÄDLÄˆA,=‚� b“@�!@�@ b"&BP b"&0M Nƒªw+ÅjM‘¼ bƒXê@a„À© ¸B³JuÞû …•[0˜ª@bÄ &B&Š˜ˆ	 1b Ä"Àô#P˜¼ÁE	µÎ(ÎõŒ†¥lJø .íÀÂL0ŽØÝýM¦^½öKÈé °ÖZà:“¥l®BƒSae-”Æ‰rÛ
œµ1(òTà2¢¨Jú« h›ÏÎuÑÕ:ÙF/Î‘uj× ¬ë¶ Ñ�Á¡Ü‘ƒ¤š­È¾o:geÞÊê|ì‚nr+pY	³¬â[	¥NÌÞ¼ª‚´R¶&^l«AñÞ9MkÍ¬>† ë”óœ}ÿnÈ·åf!Ê�›*ÚfE›1†ûöæÄ…8¨ÇºÌóàÔ«VIÿ6(@Ý6°º|¿\V4Ú)L¿
hTÆžÈ§’-ªÑô9(`]˜}ßûš—Z‹UÒo‚Ô|'ÇÝ0¬ç‹È±	aó"é?!fëZûþ]ÿ6M¯wqŸáOëw÷SÓïÔ 4%PV“ý°îóuvm+E”–ö @*¡�×y ë=¶ë§OñatÞ¤ÛVõ°úËõ»©‹ƒËž’~„×­ô»Ç=§—µ´}hh”´!V—ÌöØ¶óòvßù1ÒU2}Bk.íðü„|z�ú±0Ø:Ã»½ÝÛ¶Ñ„ ›rÞ½kqy¹r;týS_§ûË�» 40ý
(–µ{¤[ÏW³}Ý=nÓwsnÛø4>2__¨‡±L#1¬ejÆ§¨—óId\õ”ô×@�p…ùqï—m:Óõ®Hú( ÖƒÝ—‹6}T: äœ]ÜïÖr�Ö6¶­9¥À–9w�¨×·¬C3 Ð
MHge¹¡}~w¿|úø‚Ç~tÕƒ¦l\uì�o×ÜÑ±åíöíŠ1ÆÝxØ¶ËGp×D-JA]W‹‡îÑÏ§©9ŽÌ›Iú R¥ÞknÞûñ2}›¹Ó!<B°~Wh½?<ëýõr•½÷ã{]?½¼Õaì£«
¦¯AP8msÿîýmþøõ*íèŠ˜bÜJm½LËmrÞ!%ýu@]×2îöqù¸l‡ƒsUÁô› Ä°å­‘Ëk]E¥yúb¸Ÿ^Š}ŠI…¦B¬,E›=Ü<Ï«­P¥ª	r^|xêí~?m{Ÿ=Èô  ¶•ê‡ç‡ürÿTÆvt„VhúÏ@ œsöO�zùtºâq×„ª Óo€€ÔmÎñÐïq™º]ß{Àô N´áØM·åÆ¦m�T!²Ô©}þüù»——?¿¹Ýí›×O›íú}€©ÛÂnÿ0¬·ûrsbãÓ>wúzûvW Óo€ e+Çç±|{úzA³;˜õ|ŸECÿ´½¼f7Ä½À ¦°™Û¸we~c‹ÆïFëõuÅ»Aý0ý ×î›u½¡=ú¦h%ÓO@ª–ºäðø8Þ?½\ ‡ÁW©@.ÀplëýòZ´ZÿxhìúÝ’‡xT
Èôc€­+ÃsÛÔÓEíÑu€‚éH•zÇÖ>=€o—›78WL*4ý:€Ë¼¶Ç÷zž¾½Èqè£yT%Êf²vù~y©MÛÑeK Wý¾ÅzºiÛø&˜~�kuíaìÎ×KéüaÜßîçÉ†çÁ«)@A™«�§M—ÊÞÉãpÈËi¾>„>¸MÄÒA@2
›cÛ®ëÛ¦£ká
UjžÍï[ß¿ÝÊÖu£Â(i¨s…?¸š—»¶"«¤ßØ\ÇÈÓ�ÝÐô*¦¦`Y·:îŽ†ÛÛË0ÞQÀô;  u-.ô½lÛ}“=AH]·5Žï·×³´ÝØ@`T`ÍÖô�ÐÛíÌØî K=1nÓêö‡¸Ü>eâó¶�Q(k]äù]{Ù^®‹š—*Ê<Ínxv-OßfBûØ*.§ï°kÇ(2õ  Î[vÇ£[^¯'šÜÀò"ÍøÐÏëù\Æf€@H]Õ}°½nS74)‚Â2Uß:w»^�!¸ãÜùüîM»?> ··Û©kötY@×²‡£žî÷²B4>ìÃt:ß�nh gT©å.®ß7¶]O.@Çã³êËË©Œûf?~¨óézÛvCçŠ�©!V×q?0o/–÷!ìwƒ­ëÛæ}«æÅÒo‚)•hzØ<ßæºÃûÝ|þÅÝÚ]ßÎ¨°%#îš{™.KuÕ��Žv=�âþQ}50u`òÈuqí‡§p}½ >Œ‡Ø~7¿Ü—Á·*€Õ›ùî8t—Ëu‰¡ƒfÉÜ4<µ~¹-fƒc»Û5v?•²oZgN,ý-b¶N%,çO÷3úÖ[ò p©Ô}§õv¿ÙÞ÷K@Ëš-ìG‰—×íä†ÁC‹¤ˆ•\Âƒ?­¯Õ8Èðz\^W ;0Ì E6YÑìûi�/Ë\Ü=‘ßÞnþ¹ë<˜<¸ÙÝuO=ËõÓß?À­·éÓ�!ŒÏï«-§Ûò°k½Q³Uâ¾�¼Ÿ®•ƒk¸».íŒ¾óJúë ˆ•esnßÁæÚîƒ›n—vì¼ß\ò°mÍòøô(ÓëòÉÇÐzoç%úÖ-’¾ReññÐšMgâ8ø.«³4€"fk.M{hx?MuèšfóÎÒ Š,ÃøPÖõzžÑ÷ý®[e½^°ó-E mËAw»ëå¼¸nÜ»i~¹_ömç¡EÒ BX¶©øññ0ß_²Ô6vÕIÿ±\MÂÞËE:�jÉƒ¹®ªÏ}·-o‹]ç³s–¾!VçÊæÐß¦ë}ÚûÑ×
±ô%(beYÑî»hÓÙ«„0zØý²YèzÉÎYú±ºVç‡ÆÕmZVCìŸ(o×û¸‹€Š¥ƒ±š}Øí»s>_Öaðãa®¯p]×4f"–FP$cQ9„ÈmšMC#^ 
ÊÝÐí»üqy[¶]UŠØV7´Ïìõz}“æa÷Çe¾¿`Îýá(óí¼MZç7'–~a]ª…ñÊ6�²bûø0N—�k9†>:)’zPÄlÉÒì�—ëUa}|Ø¯åíZ]ªK_�"5—¥ÇîŠëÍ.ö¤SªÕ­dÙ= îòZãÎU¥¥ˆL£cÜø¶ÎC·P®§	86�PÅÒŠ”² ]ï]�êRÅ9WË”K¿ç—åuyuû®ñ¤
Q6+ýq·—ëííÕùîØË"÷Ó¥úç¦�˜•	Ö÷¾Y–lì} 4y”Z%ìv�–Ûyš¡&–~
Ê’wâ¶ÛtEÛ4ýq_ÜëùÕû¦q~sbé=(ÂR™›~ðX§kÞ¾ß:¬×Kö¾Û–ËåÕËcã|V±4€"Ì’K;¾Î§.4Ù‹Xú Š”µ{/y™àD}(¾Ìy±îqØ³\ÞGí}’F�%Wø}€m·	êU( Ë‹±ß?È­¼œ‚í› XêA‘º–Mûýx¯—sE;*%Àš'Ã®ÑûüÊà:B˜~±\&¸ÇvhÖë©ðà££IúMP$×Bí÷;åå®µé	EÒ¯‚¶nDÛÅæû�¯æ5� `Cñ~ØyÞ×síbJJ-9[³ë`óz±¦ÃØ=t~º_gû*%ý
È­¬.Œm,÷óE½÷Á™×ô+ ål!Ž�Ù2ß°jè»öÎí:C½uÅSÒ`Ù²ua�`ëº6Ñ+%ý%°®ÕBß+6» Jð‡qÐm>-Ðàš¢Ðt ­Ìj±	®,«V/Ñ„‚Rf•ØÄz½£cvýñ’ï÷•}×:WUÓZ^ÝÖªy½\]bQ¬¬¬Í¾ï‰ûzi«kÅQÒß ™Y�ïG¡MKXÕ·ë€i½	{é%ýE°¬ Ä¾wežnÒª¶ð&és°nR\£G>/‹WmÛ~F^¦Íµâ÷]ã×uºuÖ4ˆE•¶¡ÄØš|¿^šÎ»¦Âkú5Ô:ƒ:tÞ¶ùîéÔ‹•yÛÔ�"—éæv»ÇºÇzºÛÇèÚš3â¸¯ýz½ˆb«Žª 7šó;óÌç)¬]W·å|mZEWÊºA¤m•|¹Ð¹8Aeš.Ý½‘¶m£¬ó$îÐt
TÍr…ú~D¸–É#xõpb©RxwG—ór�9¢õ’P¤”Y$Œ£Óm›g¿sÁ;8I#h¹Ò|?:Öõëbèc€ÙlE­íc·Üg(âØÍë}àºvwçåîÜ!Æ¦À¥ïÃ,›¸ËTJuÚmÈóõR¥óæÕÒ;PÄÊZÇ±qyºß¢÷ŽReÛàÚ¡…Þò­-£FSÖ¼š�]—uYVWû0ˆqÚ&aÛ]Ô|»+‚wmQW¡\×ìÂqßûå›U�MïQT ­\Û!6Õ–y«ôÝèB©×‹µÎ5UbäZÌ�]›Ë<âÛ¡óÆÛLhÔ	Ô­ä04"y�4"KïA�Tp‹]EÎó¹ö�kœRÀR65ß6¡Ú2çE¥CgùºL.DR$�°²e°í:“|9ëÖhGqÎRBªeBÓd?/÷œ¥ñ£ïM§¼ó~ŒM)y¾èšæÐZÉWŸÕ‡ 
XË
×ˆ7]–R¤Ùu>,ó2£RëRàÆ¸ßfeïª æÕ´}ÝÖ«vÞÇ‹  ³˜kbã·r^×ÑuqÇp?/›…à¼ËÅ\Û——9›ê
AÝ„4Š•iªÅ‡þà}^îsdã�£¥Pr-nØu¾Ü§i´µP	¦€+7Õ}p°	Õ‡¶‰~µë2SÛv´¦nK^E4ªšBÒ˜<Š¬æýèeÉk.1î@lë­®®x¯RYÐ¾ÚRƒv~/Ø¦¹®Þ"Z±²qkBçc)ó‚Úh£T—z$ÏìWAì»ÈµÎ4„`’¾€Õ²ˆv>˜Õk_5ÐÑô#T[iû³Ý·ë 1x:jÎ¾ó¾–y^‰¦ëÄ,Ïk¦“V¢IúVòBm+9ÔGÕ4‚VV�óCÔÍ¦e1ÑMM?Q7«N‡+ïÛ}‹Å;…J­K)Òc>—S™eôƒyQ@R’5—BÇ ›ÏY�¶½×²ÍsÙïXËœ|®ó´)bˆ€ËVƒëý°Ø–§ŽÞzJ¥Iì;`^VF�óT­u-Ù…±·Ü×²ŠL¤ ÜôîuèX¾ÎcðÁ¦GP„µd“4ï²A$¬nV]GoËiÁÞ7¼‰JjAX¶¬2´.[¾-�5A=US’V­¬NãëvÕ¬Ñ«ƒ¤=lÅ½ÓG¯º®¯ûõX‡e¬šþ’gA6ßt­ºí¶Í%X@[EYu§Qò:oV‚6Õ	ÀtPX6±�|‹eÝ&iœ
Ab€±–²…ÐF�2¯ÅœUJò @Ìj–´…/yEÔùJ¡enâü(Z¶Û¶ŠëÛ�`½åºzxu„²s�6ZÖ¥fGÄC„L¿
¨–=¤ñð%—ÕmÞ©wb¢é„™Ð²Ë®�¡©ùVg0¢¡’¾’ 1û|¯ªùVçÒ„±–{Ù„QMÈº¡JßÍy]KPáT–b>¨®XªÂw¡[¸m¹x'>€"é·A£Šdï‘b‹e (PI4ƒ�–ÁÐ¸(y¹œy/�ô�„	k)ˆ¾�q]«8Sïœ@Ò�a‚Z²‰o ²r«
ñÞ9“ô/€fÂ6¥ô¡ñÛ¶ÔªÅ£1£m!7mˆÁ8/¶?ÆPdÞ2,"x Ôôk¨ ¡Îl‹ˆ­Ù(æé Hò L„,u.4 ËœÍqp^l]K�ÚuÔ¼,uó­k•*Æ‚ª¾iªØj›¯TÍ,ƒÚ4TTlnñN½#LD4}&Za¨ÐÆGÃ–éÄµ1Âf®éÄ)Ä ’þUÐHñ¢Ì&5htY7dTº`É"és“‡±k‚æË!Æv Ë9¯ƒ´¡-•S®Pq  ¡ÔZ©ÑyˆÍn’W1@ÒH€(RªÓ¦ú¼®Ùb3”PóbY¼w °äZàUh\”àUYXIQ�ª%!«UjoÈFN0 "¸ˆß…þMà_Š	*a …¢  P4@€0 aPŠ@
(j&ˆ� E@PA„”
!
 ‚ &j¢¦&0ÀäA5
M ! !‘<M„"'UÒ¬ÍÔ  H(Ä©ª#ˆâ¬Z…Q ÞiP˜Y–Jª¥€Éƒ"ÌHÂ‰óÁÔ™•º…âH$¯P¨AP(Ô Š%O êUVif h´Zà\ÓToXK©¬æ«7�¤g�ÈnsŒmlhëšÕMU¦'Ð¬T“Ðª7®eóUU½Jz«Ü.6­ç²dJë‹&éˆ"¹@Â±´Ø¦íÚ«xé«‡gÞ�DUÁJ+pÑy‘­’…ê½cjAa­YªAQÖµZ€Ó`�ô¯ƒVkÉ¾wZ¶µ DŠcAa-[uèüHË§zG�è”Âô#PP™53ö1Þ·M�úÖ\ú; •¹–±y¼êuBíb°ŽL;PÀb5ø¾s˜×ˆªðÎÒO@³dø¡‹sy“ 1z	 °ÎÈ~·ot½½™×T5M@êZsh‡Çe»¾m¹mZU(ÐêìJìúÂ[½4Ý«¤¿Êæo[»oŸ±|‡»ûìýŸüðšþX—)óñésä„ÿÿZ„þ@ÝN'‹í¨€Xú�RKÙ�ï—ïtc«)€�­nÏÇ¦\>Íe<8ìwîv½ÕÐ4QLÅÒ¨7Øø´çí|™|ß5jB ”bÙ5ƒ”í¾tÖvpEÒR·yêŽŸ�/ëÇ¯¯±‹kwø|œ/¿ø9Þ}~(40}	R·õá]cß}:åøÙÃ¦(ÈÙ|ÛxNÓ•è¢÷EÒ  [^£>,÷·MCô¬*–~B¬Ì‹†ç‡ÌÓ9·¡5ÅÓ#î§�«ìÆÔÄ(ÀR§qüâ©-Ÿþ|ÃçCÛT‘
Mï@@J™sût î¿8‡vh ÓP€m³ÐîZ=ÝNyèºPàŒPÙ¦›¾úì¿Åw
`8JÛ®®§+vžÚm³mo¹>¸à‹Š¥„Øf³4{¬ÓõEJÓŠi5€Ral÷[>[¢ªPËkñû=Êr~›ä¡u Š¥Ÿ€+¥ú×õvÉ¾ñæÄÒO@@J¾÷Å÷qùöçox|rY2M?Ô©4þ8ôËýlhZª€¤J)Ó†Çñ±¿½Î³�·a‘4‚ Ö2Ý†Ç'¬¯¿øø6>ïº‚BSÒY�—Ÿ>¸Ëùëe}ÄúçÏÎó§Ÿ]Ñ>ù&Ÿší|ZrÛZ<<Á}z;¹í(þ¸{À|ú¨[BÿîIíå„¼og^ª¸Z¯Y»çwy½^Ï»àl|ÿPðí7çklûãóþ6·,ºæp€¿¿ÝÙíÚ `êAˆq[évG±ût¦s5w»^_Þšq×AL?Øº {ú×ËkÅ¾’	¦÷ PPoëôî³úvþéý½è}ì‚â¶¨zh‡²æµm¼JÌ$ÛíÊïÿÒ€Ÿ}}Æþy5ˆQÒA ™ÆýÑÝïŸV»@M)Ì“øaï·ù6‹‹M�KL¥Ö[vñx˜¶Ë§i®Õ=ÿàøéÏ¿Å?}~ŽÎŒlÓ[3|õKø§_zý“w}ï†¸w·ÛuÚ�mKƒ¹MçìüÃ~?Ï—Í5�¯#T¶2c÷þCW?~»Œí ]³6ÝîÑ‹Êáøî—ÓÝ7è†½Mó§»ºÖ›Lå¼b÷Å°_^¾ÁöØ�E_N×Kì{›Ÿo·ÉvÍ`ðbéHWe^½Úçr>ÍÚ´ª¤H±ÕÚ‡–¸Ÿ9ô­ˆ€i dÛb×·˜oh{ÄÒ’%³o{®ËÝwM£â@ˆØmÊý?êÃôÓŸÃÿà¹h`úe�ºÌ«{|Œáúi«ýNšÐô¼¾næw­bé+b¶mÒ�;ž¦ŒQv"¦¿bëVÚñá1æ×mqCT[ªÅqPYÎj¡Æã{Øýõí²�]Û?L//µïv­ùjØí–Ÿ¿ÿ¥¿½üô#ð>2>uÓô¶6Îív�m÷7‡ƒ„nx®ËýtŠÁ³kv½¿äÐ´;%Ä@1LûAÖå>uN:EÒW €:íÃå~ºá8ª‚é_bVˆC™Ö¥xè	˜²Þô> Ÿ¿�r?E`ê@@ê²lÍîÃN–—â‡½‡€L=H•<Í¹ûðƒ‰ßüâþƒÃC—µ˜bu©û>×eVkÛ@HA@ê²åö¡a�?Þ›ýÑEV!œ•i®íç¼}³Õ‡a¨ÐL¦w  –Ë­=|oÇùgß�×§±«F€éAˆ•µ¶}×¬ËmÛ¢µ€HúeP lK)ûwÆËõ›Ùv!Ä]ÜétÚt¯n?ìt»œàÚÐ3T2½ÊZ§ýø½§_wÜO3JêA e+±é‡á~]BÓ˜Š¥w @ŒsiÚ#dš&u¡¯T±ôW@ˆaÎ+Ÿ?{ÿóÛ7Ë|Ø÷Ý–E*4u  Øò"ûC{›O')M´L=ŠlëœÇCÞÞ~vþeŒ40}
×:‡þC´íõÖƒuYªÀ°Ö-ûÛíŒ¦Eøl|^—×ùŽØ´ãÑçõuù$�±öc˜ï7y?ÀeKïA�îÁïv±žï³ø.
U,ý§  e-®;»Ûù^|3Âg€b–KÜ�Í:Ï·½Ä*’>Ô©øîáÐ–ót[GßÈ¦`@ e+~·?ºõô:ã9vÔJ¦? ÂuÉ|øÞ¾ÅËTã®éWVÀ2oÞ[áy>é*uxø^?}ûçxþp0G�©!f3K|èº�ÛÛR»6ºêÅÒß‚uÉ6~¾ûæüÍŸuc³K(RË½Äæx\¦é²¡ïÐÇnYÎëÖ5;¸±Ôƒ ê­®Ý»ç#ÞN—fØµý]Ô¨R¶Å‡ý.ÊòV¹÷±4‚"µ®´¦÷bS)Q‚%Ö%—Ý®–ù>ç¦ë¥’¾Éµæîñ(÷ùãælèƒ	% ˆ•e“î›¼ÞÒGK?E¬L†öÐ–åØõ�tbé=À–ÛêžÃøòñýnèJò X¾e|âÛ§Óy¿ëÝ…X×·[;4ÁQ	H)×y÷ü®ï__NŸöÆGK„X¹žôòñíCSµHú1ns‰ÝC——ËG”cïbuÉƒuÍðCO›ï³SL,} be…š|¹_ÊÆž
H@‘ZïÐþ0ŽËüÆþÐuPŠ¥¯@‘Ìšñ¸Óm:Ù<Â?�åí|»û¦´@ÅÒ{P$cŽzðk^‡�ŠZú	(¬êÃ±sóí6çVK_�"ee�Ã.”ù´ hžÞ·ËwŸ^r	ã ÀÑÒ Š”­PÆ6pYÖ¨h,yXžW×~x‡xýô¢Í¡k*-½’mcwŽçûe»sü®a¨—»ÝÚ¡¹ÈršíÐtŽ*–þaY¦»÷áºž?¾�Ãà¥ˆXzŠXYf„cw¼L§“ÏmÏÛü²,á¡ñ¡˜
ªm‹4ã£éz¾nð�sEÄÒï�"Vî¥Æ§CÔûÛ¹´C7ºNŒå:eç(S@áBì:ã¶¬�ÒˆŠ¥¿Z®*]ë¤Ü‹Á‡>ýeÐrE3Dç¦y±ƒ:“´E¬LÌãx ç·«Yß4íã8æË9wáÐªËK,k±nxXÃ}:S».˜£Xú
aÝæ*‡Ç†·ëéÜ4í>Š‰XzBX×¥æ‡cØ_¯/hžÇè«K¿Š˜Íyñã‡®Õ—×«o†±/Õ©XzBXó´Éøì»åôöfñ±küÿ_¼ìØÚ]g~ÇsÎï°¾µªj×þ÷¿í("vb#�clB'qLZà EÂ²B	‰zˆ&RÚ0Eƒ‹H�Ü�ˆývíªµÖw˜‡ñò<¤xþ÷`/î6O!´m}UŸ-ªKþÐ÷Òåô|úðùøtÛÓs˜cƒyþ!¼×>ÄÓ`ì;!“„ ùç  mwèãÓ‡7\¿­¢ã)™ä¿úÞ]æ}}}£rN

ˆ*§qv9îm=«Y äxÛ«O§eìõ~íC�¹‹iþ)¼Eãé2°­+ýS Kþ‡ ·]<QÜ¯Í%&	¦yE¼ÅÃp9¾êlLbPÀ‹—“õþ¹b>Åè.âùP„½ÔÍìá4¢¼½†).sL�o»¥Q'°m¬ã¸X/ÛJ“9ŠR<ÿìµXfNkÙnœ›kÐü[`«Åcš'ñºÕM*¦ù¶z:NçØîŸP¦(gWhþ.Ø<¥‹±ï÷-`H( Ž’Â2‹Ö·CÃ`CMÌî%4ÛÑ”MóO@G?è>M§èÇz=p	Ë|:ÛñJ&› 
°ï¥bx|PÝî_}Ò4Î= ÛáŒó,ñØVk>hêÁ<ÿ(Ò
÷8¥j»¡Å„‘ªù�A4Ù$èeokYb
Fèµ#Åy2]Ëq’`ùöVšÄ4%”ýV€¤±›ä3ÈV;q9›s;Tžú 
Ë?áì¥„>ªGY_«¨�'ê¾nG‘4L“½n+C
‘*ùïµ›§a4ÔûÖÛ 1ÐÔó— ×ÖD—I¼—c’©hþ' zñd¡bõf¢–¨š�¬(‡Ó ¬o[í0	©‹ä${+=Åa¤Ôõ8 c41££Z1œÂJÙö.-š˜åï‚^ÙÜÆ )½4DDÍ°·CB<MÒ}eƒ bpÉ÷„x‰cÝöqðÁCìùû é,<Ršj»Ý´'µØÕ@÷ê”4Ž`?ÊaM“˜å_€Ž&E›átð^÷†d‘|A¯w´q¾œ¦Oõ›Â‹Î÷÷wÍ¿‹Ù««CH�÷­€içˆ~ì¥"„A,hþôÞwõ0Ä íØö&ƒEš’ÿHï½yŒA´]ÅB„á­7�!…ÖŽ¶hÔÝ7ÛÒ4«íííš`Ã’A/ý�† ¡ûÑ*ÕÅbWŠæ¿²×c¢µ‚*#¢
�Þš›%µRÛ´K
É3gÃ0ŒgÊÚî±¤  ó{ÐÙàˆÑ¬·Þ„&�jù¿ÀEÜ;�BoÛ]ÅÂ�zr {Õ®ãQËQ»‹0ˆ÷ZÁtŽmßÃ¤–L y�Þ,†`½­Þ%è)z;ŽJKÃÈ£x·.1ˆ’¿ ½zL1=vKÉ?ÉîU’AëQ{÷!�BËæÝ\£…H~	iè­�~ì[áy|jðízåØ‡(±	Xkó´<ž‡V>¯#“Eƒ€,p†å²ÜÊëµôñ2,q J©•ŒSJ±·c—n”ˆ(’8‹C¦4„^Û
šhúŽ]Â4Io·C"†1¥ØZéì`ôè’gPÄ}Ç:Žgàæoo¡¦h&žGPà½mð0Å½ï›Ñl>õ¸—£¸«‹°WiˆÕo^i:Hìù÷Ê[4ô¶âA,uØ½u·hKiMdU×ÒŽÐÜÌ”n{‡<Nf·úæÝÂ4xèØz—(š¨
xïUS—»×žì<a©ÅUÅ‚˜Hþì^«4›§±örW`˜&˜÷;]0yD0Šæ�^[“0/¶qÝSW™`Ï#( ØjQÚh†¾µ^eœR{é t ¨ �-¨EƒøÁÚ fP’½µ†1©¢s�-˜3HÃÞ!çqj½ì›Aƒ«x¾À¨	�î€äP‰ÆîH!5©ÎhfÒ{E—)m?ŽnbÙ÷Ýš„ ½îHÂ ¯¥’â)Dô½6D—$*$xHC<%A»–jâ0Rv¯ÚS@šZ|˜D¶Ûç]‡a”¡$$?ÃÙàfQµ`+’«å3Ø¼¨†ÃáGA�0‹T¼SÄÆnh¥›»ª@ò ¥³·I­õ;×PcŒæRV¯
³`.Bc>ƒÞ½6„à½-¨usÒ[ëG3—�‡*ÄÉˆ“ì Wë:Û`ÞöuhqãÔûÖ›!!ˆæôî­kÉÍ[wBWqé�I;ûŽÞÔE5  ¶Þƒ&u«èêªÈAš5Ñ˜´UÌ¡&e+Ímˆ3Ç¾îÒ—8�SóÖ"D(�üÐ] h­D›RÔ¶Õûèaž’yÛ%ÒŒB\@@è<¤†ažq½Æ.Ó’°ï¨ Š¥.€@r€‹v¸ºÓHÖV)´`A;»»ÄDY¤;EÄ�<€pvB‚$Òw-Q`Í¿…ÿýÏÿåïtv‚ @@˜(¨C(A8…„xN�.¤R‚ @ ¤”œ@@€!„ t8�† &HwºÃ©„t÷Nˆ˜3Ò[oì *€0ˆD\„€9@Èœ@
AŠƒ BRètt§+‚'Xè�U[kŠ‰@ ‡ƒb¢Á„Þzˆ€ÁUXµu—ƒéÞZs"PÁEÍB0xg�ÝUæŸ€­{EÄcºb7‡Y5æßÁ^]ºžâHG/Ñ4IPæï�`•*Æ¨ZÚN5Xˆ]™ÿ5¶Zèq“÷µì5Â’¨0ÿ!(ð^{ð”&c½o�˜1Ò 8z­®cŠèu÷¦*KUÊvlÂyÝë­n‰ñ<‰È~_Sg˜<aþPÀÖZŸ–%ÕýåjË8©A$
Ø*©Ë÷ãx¥…$�”üÛ Š 	€¢PÄs Ñ¸ÁÇ³„¶}
ÓÃ`÷û'�”ˆ~ i^¤–ûÆ“ÙDˆäŸ‚xñjñrZêë^çKŠ�ÉB7úiLhåµNqz—¼}¾­§a6ˆ€ùû  ^‹àá4Æí~+XÚ4?~èxûTÉyš–Ã�×›Í§1ˆä/@úÑUç‡ý~ÆC*
ÏA@¼ô]Oï¿�öúUµÇ4™‹thþï @XoLóûw§ëç#„ÓYâ €Gõáò Ÿn¯�cœ¥
˜ ÒÛµ„‡÷Oe»~Ûøn¬ÌÁpÔ=>¼{ÖÏ×2?/£`þ(Ç¦i\\öûÞ4š
<ÿ„8÷ô(q-ŸmŒê*ž?‚�^÷–¥Ûõ¸Ž†Ñc“üß@ }-Ûéé;~½}ý›—Iœæ¿ è{ÕaœXîÛ~Žƒ"ˆçÒ|Oþ‡r{-j*Ïé"ëÛ7ã�ù¯@@š§eØÖ•“WñüG  ½%<¸Ÿ¶f'_|Ä¶¾üÚñ~>ï0§ä_€gÛS»˜µíÕ¢-jÚÉü%€ûÎðp:µý×[;ÏIá`þ(çNyc?¶CˆÄó¿i^tœÎ¡–+â†áù{  [ÁÓ%Êý›Ï|œÍÁü€ÂóäÇþ-ÃC2í óè«÷åé©Ô·—c~g…„ô£3].±ì/Ç ó(˜âíè!>Døý�Sš\¤ˆûÑ9,[¹ÝSˆ©GxžA@zYËxY÷on›ÍSp˜¿A‘ãØñôüQ^>}µ¥‡ç(®NÉˆºäåXãå»Ó}ûæÓjI—Ç�ïçß|ýù%.q~<cÜ¾úôm¦óó{·ëo¾’†ùòÅcñßüÍ}|z]è`þ%qß]ÆÓ©ó¾ê4„ä&žÿÈ�Û8-*ûÛO]à¨O÷ÛËqŸÎC ¬¹×¶<| o/·cšO˜?€ |sÄç©÷ë}I)X˜À�†0�ÝËm»Hbây!ÞVÑiN}¿¿M8iêA<ÿ„8g¼œÄ�[C�”ü÷@ˆ³Ï[»†Ës»^_î÷tN†. €[“áñÁ_÷O}?éüáÜÛ·¿¹Ê²ŒË‡9Õ·_—2>œOÏ—åëOß|nKŠïÓˆO÷2�5ºSò¿ !^»‡i½ßöTUÒãe©×··î˜¦§¹¶o_�þE˜�æ¿©ÒÖÃççwÓõíÓk\†wÉ?øVËøø$ëÛ×oÚÂ0½{>Ý__ºOÓ‰ê`þHo·‚éKƒ¿~s·/§A¬“ù{ Ä±×Þ}ˆr|^1½?%ë
PØo]–w>–·—R=€
´ºõéÝôú­¬�ãdUÀ<ƒÇQ�4>kº¿¾xˆayzšëýúÿbú¸Œ±(˜ÿ¤õŠtyÆp|CKÓÙ�üàûÎôn~Ú®¯÷õ’&¥ƒù/A ý^ýôîAûÛË=ŒÓà”ü €Oc`}»·6<-C¿¿p:�zÏ_‚i­Ët6lû›Ä˜$VÉ? E¼Gúz¬‰aXžŸÇýþR|II=€*½Ý”Ëe,×kÇJþñ~¬mzºœP¾ö['	âùA�8¯>,O§äo½ã¤Ö QAÓØÚ};T(ÅóŠxåÇÅlÝŽ"a0˜xþ •–ìéŒc{�,ã@ªxžA� ]—óé²í¯M.ã€nâùû  ¥îíááiÐëË8OÑ…’?‚"ÞK�á4÷ò–‚¥ÕóÏA‘Š6N†í(=hR‘Àv4³sTß_aˆ0zþŠôv �ÃiãZ{Q5q?jOÓÅÊí~+³¦å±ív-‡Ù<­øzÝU†ÁEÅó�Aˆ×£ÊüüØ^®¯»ÄÇhÝÌóï�"­}œãàõz“*=ÿGPÄÛvhz7?mÇË~­qœÍ¶·—ãM#Îï¢ÔÏßàv9ÔÚlœe¿õB„¨ç?Rû�ã‡‡tùtG‹ã`´üñÒ«œÞ=îíö©õu–aZ×¯‹âÃC1ñüG ˆûqx:_¦ÛÛõÍ1¤ØŒž¿Ez-=„çq8Ê'Ãã`ž¿ŠÐÛ½é2ŸgÙ?1†9&ˆzþsâ¾•-,_Ð—¿9t¼,â"é¥u½\.Gù|½Oél±	óÏ@‘^Z‹ã{&¬/wÚ2>œ�öë×¸¦éq~Ý^ê^/'„Fñüa•ú`Ó[Yo˜Â0¸R<ÿaó­¦ñýãñÍÛõ-¤y².êùŠx?îçwûööÕ'”Çåüh^>ƒ�æäAÄó
„ew=�/þéók¹ÎiJ.êùw@úQo!½7Ù^¾nÍÏqñÀÐëÍ8ž‡áh¯æ9‰Á<diM†i–¾­×“„1XWÞïÁçsœx{sÎÓøøn~Æ~ýv·0�ŸÆ6ìë7+‡e° ¯­ê0±î÷¤!œ‡zíëí8ø—åñ^ÖµêœFJ¾€¨€Æq6–õFÊp™åVß¾­Öß—å!´u½ÁÓøø�–—¶E
øÑ{ˆãmß_‘FŒ" Xý¶Œ¶—·{ï“žÏ'ê~SŒº@¡€·õ4<wßï·²hŒqWÍ?mwê4F¯ë=–†é²âØï˜5&°üû ˆ÷có0=ž‡~{A‰Ó0ªôü' ÅqšÆÊç·-è<"Váˆã8¶ÞÖÒ9*¦ùß�"í`Å8ÇPŽu““šhþ!Èê½/Ó)öz]E‘†¦ÐüÐKMÓYäþ²úœB´®šÿÎCjÂÀ¶oµGS1Ëÿ	E_™–Ë¸—ÿ;¯çõñ®ùÀ{éæó"xk×ml1	&ù‚^»H˜‡¡ûÚ7‰¢ù¯ÀÞjÅ0IhíðÜ]ò/A â½xg\R¨ûõîƒÅ!˜‹Bò¿…÷VTÆ@AñÃ¡i‰1íûº¡Å0Ò¢ùÃ½°Iœ—ØêZ· M¦Tcþ¶Ö*G3í~×ª¦!Š@òÿ Ž‚ƒršFàØö�QFÕ®„ä÷Š†É"{¿³÷$EÉ¿	¯^iãi´ãø¼û%ê D%ÿH
ýèUÂeœPno{À�¢
 5l6O1µõ@íÁ¦uë/¶2A	UH \Øk¥Æe­ÜÍ(Éÿdo´E“÷cwÁä‘*"ùï€¤8g8-Ñöývã “ˆª@òAw’½î¦Ùj½oÛ CŠ@�ü+�.qŒMë*ulH¡À{ë’b¬±iæbATóG°û!]¦4Xï×…†H�äÿº÷Þ%…(ÀQÙ£ˆ)¢ù÷Áî­I˜4@Š³‰hè¢p4'�…÷Ö%"HP•ü¿�ÅÙŒÁ¢’{s,@ó] âÝ]D?È&qíÚkG#¤õRÌÆ¹­·R%HRÅ•¢ùOá©ðÊf)ŽRêzT!¨+Eó_‚è9@]*8„!®¥Ó„BHþt�·ÞÝ¢±5ª!ûîUK ¡’ÿ ¤¸¸ÕäAF…jH“Á[oJÕ&t'�ü#�Pá­5�)!8š¨1º8ºPóÆÿ·Zk©BASE      -è  xÁA  ƒ°YëñÀ þµ,9TÕÙšsV3Æ\éÂ‚!Yå XssEsÒÄ­p«¶¥DAÜt‘¸�@0f*s"c!0f ÎÍRÕ©†²•jBsnš"ªm#u›¹³‘UNMÕ¹�­µ™Ìfæ†EUÈ†Z	ÂÜ“Ü¤pª„,"(†r
Â‚!h9C,„ !Ó„ 7ÁhÚfµMbÎ�
•�"¥4GLP"R	9 )‰�h•V‘E"Xc.Ø$s i.ÎÆ&04B ‡ ‚‚ ‚£C„10 a,œ¨1p’lnDAC%eÓLÑáPÑ�t0�c›¨Šf!8
ˆ,g9Ñ”D&Û©ÙõBPOS      î  xÁ±•SA E1Cä?WoÂ­†„¶(éï¿?ß^¯×÷÷Ï÷û×s?ï¯¶ß÷s*ÝyZ?œnÏ¹�¤Ïç}ßåœë©ÏºcN]O\<¦]‹mŽm5ÉîÎ5îÖÜÚÎº¶f¦»¦Ml“µ•º6G6q›²k4SŒf C2+±-5gÂ …,Ìâ0%L4`­„J35ŽlM# ÀÑ iHk$am @­	°h42i&`†ŒL±¬‰1�6€Á
Ð`h ˜dˆkÆ,,f‰�­1L0Ë²3@`‚	Œa„ƒ–1	A$ �JCÓZh`!Á !À‚L‹¦�hgŽƒþ¸;/×CNF4      `  xÁAJÃ@†á·ÑiJ�Ð ˆ¶ˆîÝ¹òßÉ<„Gñ
®Ä]]Q	H�ŽØßÉø<“‡9ènÂA(…j¤Lª±ö}ÅI^,wSöO³¦�>Ç@OCæ‹ô·î¬†£šZE:Ã-õÖv­¸é�è Õn:Ç-­ÉA÷¸)â¦%NTP‹›jÜtÊËµnqLä 8¦)‰˜¢.qª n9`‘eMÇ$¢8‰oBƒÛïÛXÍsÍûæùçFÆö,8)ú0Ö©þüå¶3�DðjŸãê}5Àt�oüíÂq>ÂŽ<áhžC~UATPATPAôÈ?ó–vƒTEXT       Ïô   xÁÍn‚@ÐïQîÀäÞoPÃ�Ö€HMº"¡1qÓØEíó÷ŒñÜC;ø€ëé8"V{cÒTVX–«½÷ÉR™f®Sl`¹™ �K‡åù9<6¡–Jî„J“ß—,Ï·0Èá±	­ôy™¡Ò0ßÆTš’ÁQ5p'©PiJGóyÐ~vúzõ…×uºLÅZ·ËŸwß¯çØ| Ö§tjRSæ8_Ú¾ðŠº‰úÚm_?¸w³!sŠ{7}-æü*
4ÓCLIP       	           [     F®ZTR

BASE      0ï  xÁA  ƒ°YëñÀ þµ,¹…3u­‰“°š90æBHçÉ*Áš›+š“&n…[µ-] 
â¦‹Ä…š€1S™�1pn–ªN5”­ÜPšsÓQm©ÛÌe˜�”@¨
pjªÎl­Íd6C07,ªB6ÔJæÆ˜ä&…S%dA1D@h�SAËb‘ ™&¹‘FÓ6«mÓpT¨	(�Ð 9b‚Á�JÈIIlDÃ¨¬°Š,ÁsÁ&™EhHs9p66�¡‰Â q8 lÈ€±@"Œ�á cáD��“ds#
bˆ*áX(›fjˆ‡"ˆ¦h¤ƒ!è¶alª¢Y nD–[¹¡()6¶Õ~Æ  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>   Ê<AlignableSequences><Sequence name="143_CMV-F_TSS20210225-027-00003_G05" ID="0" isTrace="1" sortOrder="0"/><Sequence name="P9_CMV-F_TSS20210402-028-00038_H07" ID="1" sortOrder="1"/></AlignableSequences>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ¦<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6711" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5920-6711" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6712-6780" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2873-3472" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3479-4067" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5161-5749" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2578-2846" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4141-4374" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2354-2565" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4586-4721" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4446-4567" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6781-6885" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4759-4775" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7359-7375" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>6131d349-5daa-4ef6-8768-ac1592fda512</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="7:7:1">2021.4.14</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  ðý7zXZ  æÖ´F !   t/å£â	¯] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnãýJ„<Ú§^ð–¬×~‚fÛ] �ù¸Æ^Çœ¦Î`ÈÞx¶­”2¿<z¯ÌQ…Š“Œ‰u×Ó'îXaoWóEh‡^† ó�$¤]Êoì˜^îPÛÂ ¹)NY¥ð’‹`�¥
+"ÑM×æì¯�è_ÆW^Š†¼èËÞ«ö®0Ê1Å†éøçe]§Žæí—Âá/ñÅmx#D�…MýÚ	‘É­ 8ž½ÖÔøj~vÆ$Î±‡Ô�ôYú}Í[¦Jw'æ¸1Ë&†tÿj¹ž?`ŸÁ©,3n»¾4cug•·îê·aóÚAÆ°hß)VÍ‘@®Ò0ÎŠÎ*OÚ›v}«x¿¢Ö^Îe”p}¢ëð‡z&Š<ÙVó-P…Úóx	t˜@MJÝ¢˜éoúüMòk	EŽ¸Â\òå¾Ø|pr¾Ø½à)êã·µŒÙÞBze8LðÍ›E¡ðU=ÛC{góq w‚€“æq·¦2àŽJÙ<äM%=£BŒ0nä6�ÌTÉÈo+ùõŒÔZ*)*±Ë>IGÍ	(Ú´Õr©(“Žzù®×Ê©ò¥8ŸÛ«?kÐOÄïÛ›7²§®0F•ôýƒl_S.˜ ºÚRêV!«*RÍ )ÏÎBÌ™~“„ zöÌ…ºWIø–÷YÌ“Ç›| >äÈ¢÷–¡¨Õ“
¨—Vr°iXÆÉ¨'DÛ/r|±Íõ÷“®ü­ò®jxÅýLAd¸/`çÒõÞ*½&núÅï¤7Mób—} ú´C)nã·ÊÚ¦²Ñ°’œÄÔèÛjà^Zd+é	¨Ã×n.œÞ‘íôRï=­j„QÁº@¿ÖTãAa%î¾¨é1¦«¾Ø-ä33Éÿñ†74ÎÞ|ù©â¹ý^ùAï
ilAaŒÄ¢•²Ý{G°ÏÜVA*�ä;«:øüV§n„Ó©g ¶[1øú�É©	Nƒ4Øþ6¥‘TSE¯ùÕTPxL³“gë$Î‚Ã!PŒpÕ-ì¬/šÊš¹iøÈ¦ƒž6uÉ‡A‚œÍ¾ï'àÄÕ§’ñ£ŠñöÐ§¶_+röoÂÎ}
IÇ©ºP/½+˜wÔcë¥’> ùäAnhˆÝÙ‚Ì”bôEiX+gOSô.)ø‘—,Éþæìœ‰%¤
XÚW¸cò´¨ù}ýph0Z€œVØõÒ²Ä=^$�dñ5¹ÉŠ¿_'ßƒyÿÎ+ü8·I öîþO%7ò ù±Òã8ØxÃŠº–â¼¦+¯a‚�Š"®¨�!¹ôÉÌ\H]åÖ{Ÿû|Õ×D=vÈŠS°ÊUwÊZuJ\]Ý"ûÔ¦¶u˜K°UJ‡Žîâ£¯ÝÌÅ£Ã0*ø:z2¯¦/ÖÞyÏ!ú•¬TR{Ob‹§•pM"°ÝÒ›ê)ñ;ñy»p-4ëÙT#vãm¤¿Cý:T¢›ùÆkÙ†�¯ëÉÈ™Î,�L³ŽÆ®ü²Zb°l*‘Ì¤DCì=	sŠ{F‘
à_Nu"	Õ¨NU²o{¢Ý—ZÇŽõ%˜"³ÒsŽ©•)žˆ{äø ›¶®Ê¿¼(F?ßqš{G“»Z{�ëêrÙ4Ù|N˜R)�ŒŒ®×}tFù¨Þ”Ahë¢ÿJýè{!Í›h.l.³q¤,�:^V 6ïŸ¿ :eÙ;9µŠH;“E#‰9+òm­ø0øý«·.Íù3Ì’è}„ üßþÚ]Ëg�Z/da?ôKc\v=¶ÊÔúõôa°V4î�F1U©¶ˆKUdÔN„¸pÂœn®Èè&§Pb¬Àl/Ì½ÚŠ¤,|ÿgÒ¹ ¥àhBéj¥)Üã_X�´83ÁØÁ~üÉr@%‡×eMVÅÌ?þÂX¥Rjÿ ¹¶*>T ¾Õ|¢‹è[Ö‹I¿Z€eQ(åS�GW@¦:È«C„[ÊA¡ªç”;ªhÌÉìô­«óøf"ææj1ùR>‰^_*ÃÑ›æýMKS>~Ýó=p³!�IdÊ&œäz_Óy’êŠÌvÛ	&4Í?oò…að½èñOQŽÜBŒ/I(àItKâ�2ög
Æ€GÐÕ—'ñM¼Ï‰t>(hÇ&F!Í]cl¯æè4yÜ¥ÆœÙ5K³e€F$# ùÏôq™S¬Úà‘ËÎƒúØ”)ï€äO¼³£W»™Õé!mÍ>³*Ö²Ö‰-3ÃâœJ6R¿Br,x82eWÚ�l­Í
¶öÍxµ¶Å1\OKÍÃaš#jÆöžTêÇ-ç•ÇÚsFÆK2I½§´=™yXJmî”{[j»än,Ÿ;ºÉÊºez?Dû›¼¬,ÇOXa?(ƒé4pN“º|I×œÚzþTÖFp§Ã!m#¶âaõ`3lwq§oûýŸ|)ÅàºœöF…YÜÇ«GwM`>¯¢Øvzè— Ó8ˆ|õm~”S!Õ!ÎE—ïœkÞ3‚Qg�ù{Ôü.Ar2SíuÓ=ñ—:§llÕÂÝôB¿¯¸øÅë…ZGà‰‰ò‚'ÎDFªSIñ
ŽE„vS*êF0 ™1sÏ¹³hqrÄ¿O*=	»p Myž¦Ž¦¨˜+³k{ÅäK­«@e†‡]]‚œàô×±&Kd+LÝšS§þ� @Ò%‰üÜÁ�Qü>µ\ÿ›wdÆ°!n[ÿ¾àžÙ¦�Yö€Ú¯¡UVøËèTiÅ8Ìõ}õü¬Bœ¸Ô3¢=¬Qu¾ŸîÝþ‚f>‡3Ì®ì(•Ë„¢­«žJã¤â0ƒ5T›©3%$ä2y´T¥e®9ÕÉ3wMï÷uj¢#|Ä£ßF¼‡WpMŽÓ´èEó½ Ð£ª³-'Rt™Úê.9í	ÕÂª^©ƒÿ.&ÔàŸ–øú2ro°.¿ßÈ�Ç�ždçå|ñüCØ‘X…fMD<ÿnº»…ÿ¢ª¨åœ–jºìmÛJl�jSÐDâÙôï¯ -îìaµu™‘®Ïc7d2ùY“IZvÛ˜u£ëóÃE‚ÞÚ®¼èÀÂ~´^Þ úí^åfXFÅ³OötF"Í°Ìê ±Î34OÀ÷×:1ü®X”ˆËž×óÇV\£�ÏF×†GË‚îíÐÌ�¬ï)ÕÇ4ÂX©y¯é'ñJ -âE‚4~Àåån'6<‡`‘y8‡‚xÄâœ[ó^tpå¶üòþl;Séÿ·€ÏiMµú?gÈó&“CÇ£Ûç€YþrBòiÃ!òÖZ°¦ÅØÃ�§¶K &ã¿²Žã,Édï ÊjÊ±ÃV3'ÉÛ èé<ös˜�ióœ
Å¤¨�>=ŒÔ%¢pÔóñª8šf=Ü¡q@èÔEQ1?½¤—ÎØž»Ó2î(ˆ,<ž#§,•93xtŸ��áùÓ-
�èdý¿ÏZt{*ÐóÑ½‹Ð„PsÀx.œ!jñ›gEq³ÄÝjÆO	­§sX�ZËü‘6þ>ñªå¸‚%ä?çNr¤"Ýc€‘Y» !3Í“iË×‹ô&%!¡SÐàâÖj¨EÃxßÀ. ;KQ[_EÞGµ´í¼t1ç÷<Uã´~Ò˜‹ŸÈ|i‡dò„²O=(÷
>0ˆ‚=ÎQÔY{oÐIvAáÿÓ½–Ê³¶³M<t2
²…
‰e´ß�Pã½œª8z­½A�¿V`Îž¦”
Ðû`ŽØý©®qy,½ˆZ"cEæÉUì‰v]Œweæ6åW_æ<M"›äß®˜½eè1Z¬( {	a<>=heç¦øŠc8Êo‰iê•sÈ×Î,Àõ¢€¹­±+ý¸…	JñúÊ(¤‘O:N`?×ð%Pc"FÔdÓÁÆÐY¶«H§DÔÈ)ëÚ\sAŠÖÂjÂÞH:/†Ì-e…>«x6#›õñ õ™ñ"¢Éˆ¼b%·œ¼TwÝúÙËB€7OD5M¯õoÈ°~çË™%†ù\�chkÌÎ]ÃrŒXö§oë«f—¶¨c±~Œ/<*Øts´…É_Ú<±ÞsÃ±@S.Z‹£ÆÕ³)çâô¨-Ý+.¦Ä“IQèÎ-�2ž¸<¤ö[`Moâ>ÏÄ‡Ž¯ÍÃ6üã•þ±Á÷ãÝrCÏó|›víßk)g2aB<ÀMS¢¸ïóém,@34¡¥¨ðÝ½æå¿n•vÏš'0<X0Ý�©%e?‘áE?U=©a¯‘?bgf�
?®�éŸgÓ6hb©ÖÈ(yý’™+J«ÄŸŠä²Ÿ�&ÝÄ3f8ü™¡r!¶ÉetýzNÜTË]OýýÞþ$—rÞhVaN½EÁSÔ“oG�CrY\ô®çädKnkÀúå…ú¬Øeía`K@qì'à¹ÔØRTôÿa.J>†çGÎÐ�ýß�>fXL�èéí[ä­ÞËŠ—®RO2éÒbO5G¦‚eÛ WÂÊ§[Hð¬�ä„ü	÷EÃx ´Uçaíˆ¬ÇpŠVdåÛù•¹Wk73ßÕ1‡áYþY?9ýì_â»…pÞ0Å��jÔ_zäÂØ_êÒ¡8=E%7�½ÁÉÅõšj±²ñ¡PñFEù�OpíÑÊ÷t%Íu}€J“à³§§¤Òéš~—Q�½:n´~µ,N,ÔD_'��Ü¸ËÅLya„nÎº­	¢	œIÊè?3¡ÍáÙtóÒ±ÜêCe�ª%€1Ëpùnûƒ ï¼Á€ûÜ)jÔÊÄ¨Sß¨#sÿÝõ~4»ªà2Š’FT³z¯ë« ß“W;ûEçÒ¤Îkk¿=Ej °ÞíÉËÒþÉ=Úƒœ(jo*H³Ó
ßæ
d¯Í” ©3Ø#e8±jWÐ €ÜóJÍ/„üš�åªbâJé»CåÜ:ªü‡Q*þíem«>õY*�Ç.t´7íÎŒjõbù¦ý2 BS0*F(f–®lÆs<û˜µ»|ÓÐ½kA
%õ÷Óì™k^çÐ#Ù€šT½»½9�R,Ç{pmx7¢´ 9¿¡ŒäSïA/÷Šr?�Kžl¬™$RÒS[©æS—Üs8žWÙ�¦�ðÁØAîÝ¬(IÝ{ì©ô`Iù|û­µye‰ÿõx~ i X+AnBlmBÎC@fÛ'-a/’”h¤t=•”�€†¿ð6,óqç…v XÍM
=¸Íùq‡�WtÏ¿�nÜñÀÝù6¬v‹º€y[ž¿þ¦-e½iž˜ÖùõåÅ2KÄÜ5]ª€†Ó>•Õy|+hu8õ=Q: !Òóž�Àš¿Þ+œï*ëJÀšÜ¼·›K¦=ñT¼Ÿ5ÔÌí«ì„ò ¸­s§ý?Õ�è°Í¼ã»Auúi
æøŸukZ©ˆ;Æéc¢ÌÚ¼.´ÄÏÐ«Išj]iªIÙl‰Ž‰2GíõQÓfEÀˆÍÕì] @´°vý	Ô�©Fut™þ+^„ˆ÷øloÀìíû–iš4¾P}©×.7Ïwšó¸Ø~Ñïè�ÆœÑ¶N[Æ4¯„°*× ä�#%¿MÂ—w¯Ö…
÷QÏ�p˜„·„!DDÑ¤äó”×ê©3z€   7øóSJþ„˜ Ë!Š˜ 	æý±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  &ã<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="0" name="M13 fwd" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8621-8637" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6021-6037" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8043-8147" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="cPPT/CTS" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1804-1920" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;central polypurine tract and central termination sequence of HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5708-5829" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="HIV-1 Î¨" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="458-583" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;packaging signal of human immunodeficiency virus type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5848-5983" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="234-414" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2010-2213" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="EF-1Î± core promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3616-3827" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;core&amp;nbsp;promoter for human elongation factor EF-1Î±&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="3' LTR (Î”U3)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5403-5636" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;self-inactivating&amp;nbsp;3' long terminal repeat (LTR) from HIV-1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="RRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1076-1309" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The Rev response element (RRE) of HIV-1 allows for Rev-dependent mRNA export from the nucleus to the cytoplasm.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="5' LTR (truncated)" type="LTR" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3840-4108" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;truncated 5' long terminal repeat (LTR) from human T-cell leukemia virus (HTLV) type 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6423-7011" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4741-5329" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4135-4734" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="16" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7973" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="7182-7973" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7974-8042" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="17" name="EBFP" directionality="1" translationMW="26900.04" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="0" maxRunOn="3576" maxFusedRunOn="3576"><Segment range="2302-2304" color="#3366ff" type="standard" translated="1"/><Segment name="1a" range="2305-2307" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2308-3018" color="#3366ff" type="standard" translated="1" translationNumberingStartsFrom="2"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;enhanced blue variant of GFP&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="M,V,SKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLTHGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITLGMDELYK"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2296-2305" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="19" name="3Ã—Linker" directionality="1" translationMW="648.58" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3576" maxFusedRunOn="3576"><Segment range="3019-3048" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="GGGGSGGGGS"/></Q></Feature><Feature recentID="20" name="FTL" directionality="1" translationMW="20020.16" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3049-3576" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKREGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSARTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD*"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ©<Notes>
<UUID>eac89503-9f81-4ecc-8b91-585e4e02203c</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pLV3-CMV-EBFP-FTL(human)-Puro</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="6:47:59">2018.3.13</Created>
<LastModified UTC="9:50:32">2025.9.17</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                              ©<StrandColors><TopStrand><ColorRange range="0..8645" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..8645" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
